TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries

Completed

• Conditions: Low Caries Risk; High Caries Risk
• Interventions: Genetic: high caries risk; Other: caries activity

• Registration Number: NCT04066101
• Lead Sponsor: Recep Tayyip Erdogan University Training and Research Hospital

Brief Summary

The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene polymorphism on caries risk in adults.

Detailed Description

To date, genes can be grouped into categories based on the factor influencing dental caries. The major candidate gene categories to date include enamel formation genes, immune response genes, genes related to saliva, and genes related to taste and dietary habits.

CA6 exists in the human saliva and has a critical role of buffering, immune response and taste.Toll-like receptors are expressed in the tongue gustatory papillae where they may initiate immune responses to pathogens.Genetic variations in the TAS1R1 and TAS1R3 for umami cause perception of these tastes differently.

Study Timeline

• Study Start: 2018-01-15
• Study First Submitted: 2019-08-21
• Study First Submitted QC: 2019-08-21
• Study First Posted: 2019-08-26
• Primary Completion: 2019-10-15
• Study Completion: 2019-11-20
• Status Verified: 2021-04
• Last Update Submitted: 2021-04-12
• Last Update Posted: 2021-04-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• adult be between 25 and 44 years old
• subject has DMFT (Decayed, Missing, Filled, Permanent Tooth) ≥ 5, or, DMFT ≥14
• same oral health, diet and socioeconomic status

Exclusion Criteria

• systemic or genetic disorders
• orthodontic appliances
• pregnant women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
low caries risk	high caries risk	100 adults will be allowed in the low caries risk group according to DMFT index (DMFT ≤ 5)
high caries risk	caries activity	100 adults will be allowed in the high caries risk group according to DMFT index (DMFT ≥ 14)
low caries risk	caries activity	100 adults will be allowed in the low caries risk group according to DMFT index (DMFT ≤ 5)
high caries risk	high caries risk	100 adults will be allowed in the high caries risk group according to DMFT index (DMFT ≥ 14)

Primary Outcome Measures

Name	Time	Method
Past caries experience	4 months	Each tooth will be examined and recorded as decayed, missing, or filled (DMFT). Caries will be defined in accordance with the World Health Organization (WHO 1997) criteria.

Trial Locations

Locations (1)

Recep Tayyip Erdogan University; 🇹🇷 Rize, Turkey