Genetic Variability in Taste Perception

Completed

• Conditions: Healthy

• Registration Number: NCT01841710
• Lead Sponsor: Monell Chemical Senses Center

Brief Summary

This proposal describes a pilot study aimed at determining whether genetic variations in taste receptors determine differential taste tolerability of pediatric medications.

Detailed Description

This is a cross-sectional call-back study of taste perception and the relationship between taste perception and taste receptor genotype.

Study Timeline

• Study Start: 2012-12
• Study First Submitted: 2013-04-24
• Study First Submitted QC: 2013-04-25
• Study First Posted: 2013-04-26
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2016-03
• Last Update Submitted: 2016-03-14
• Last Update Posted: 2016-03-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 90

Inclusion Criteria

• Adult females who were previously enrolled in Efficacy of Bitter Blockers on Taste Acceptance in Pediatric Populations Study (Protocol #809789)

Exclusion Criteria

• Women who are pregnant
• Women on drugs with potential serious adverse effects that are mediated through cytochrome P450.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Psychophysical data for taste solutions	1-2 hours	Primary outcome variables are intensity ratings of pediatric medications as well as a variety of generally recognized as safe bitter and non-bitter compounds.

Secondary Outcome Measures

Name	Time	Method
Maternal practices and perceptions of medication use	1-2 hours	Secondary outcome variables include questions related to maternal practices and perceptions of medication use and compliance of their children.

Trial Locations

Locations (1)

Monell Chemical Senses Center; 🇺🇸 Philadelphia, Pennsylvania, United States