Myotonic Dystrophy Type 1 and Resistance Exercise

Not Applicable

Completed

• Conditions: Myotonic Dystrophy 1

• Registration Number: NCT05036447
• Lead Sponsor: Norwegian School of Sport Sciences

Brief Summary

The purpose of this study is to investigate the response after one bout of moderate-heavy resistance exercise in patients suffering from Myotonic Dystrophy type 1. There is still doubt about if these patients could benefit from resistance exercise, or if this mode of exercise is detrimental to their mobility and health. We aim to monitor the subjects during the recovery phase and investigate recovery in several ways.

Detailed Description

Myotonic dystrophy type 1 (DM1) is an autosomal, dominantly inherited, muscular disease and the most common muscular dystrophy amongst adults. The disease is characterized by progressive myopathy and myotonia, first evident in the distal parts of the body: calves and forearms, further progressing towards proximal parts. A recent review by Voet and co-workers (2013) concludes that exercise is safe for DM1-patients, and based on our current knowledge, DM1-patients should be able to gain positive adaptations from exercise. However, the physiological outcomes of an exercise stimulus are not well studied in this population and because of alterations in important Ca2+ handling systems the recovery processes might be significantly different from healthy muscles.

The aim of this study is to investigate the acute responses to moderate-heavy resistance exercise in DM1-patients. We aim to establish a timeline for recovery of muscle strength, measured as maximal voluntary contraction. In line with this, we want to investigate if any muscular damage has occurred with both direct and indirect measures, and possible mechanisms leading to muscle damage, i.e. impaired Ca2+ handling.

Study Timeline

• Study First Submitted: 2021-05-10
• Study Start: 2021-06-14
• Study First Submitted QC: 2021-08-30
• Study First Posted: 2021-09-05
• Primary Completion: 2023-04-30
• Study Completion: 2023-04-30
• Status Verified: 2023-11
• Last Update Submitted: 2023-11-27
• Last Update Posted: 2023-11-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Confirmed Myotonic Dystrophy type 1-diagnosis

Exclusion Criteria

• Non-ambulatory
• Injuries to muscle-skeletal-system that prevents resistance exercise
• Severe affection of the cardiovascular system
• Cognitive affection
• Lives more than one hour from test site

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
Change in muscle strength	Baseline, and 5 minutes, 3 hours, 24 hours, 48 hours, and 71 hours after exercise	Recovery of knee extension torque

Secondary Outcome Measures

Name	Time	Method
Muscle protein breakdown rate	Baseline and 27 hours after final session of resistance exercise	Rate of muscle protein breakdown in m. vastus lateralis between baseline and 27 hours after final session of resistance exercise
Muscle protein synthesis rate	Baseline and 27 hours after final session of resistance exercise	Rate of muscle protein synthesis in m. vastus lateralis between baseline and 27 hours after final session of resistance exercise

Trial Locations

Locations (1)

Norwegian School of Sport Sciences; 🇳🇴 Oslo, Norway