The Effects of Acute Resistance Exercise on Protein and Amino Acid Metabolism in Chronic Obstructive Pulmonary Disease
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Sponsor
- Texas A&M University
- Enrollment
- 57
- Locations
- 1
- Primary Endpoint
- Change in net whole-body protein synthesis
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
For this study a resistance bout will be performed in order to promote the robust response of protein synthesis. Type II muscle fibers often exhibit more atrophy than type I fibers in COPD subjects therefore specifically targeting them in an exercise protocol could have more beneficial outcome for these individuals.
Detailed Description
In this study, the following hypothesis will be tested: A bout of resistance exercise will affect the acute and 24h response in whole-body protein and amino acid metabolism and cognitive function as compared to baseline values in COPD patients and healthy subjects. To do this, subjects will complete a baseline visit in which they receive stable amino acid tracers. The next day they will complete a one-time resistance exercise with an immediate measurement of the amino acid tracers, and return 24 hours after exercise to repeat amino acid tracer measurements. This project will provide important clinical information on the whole body protein and amino acid metabolic response to acute resistance exercise in elderly subjects with COPD, as well as, the exercise induced changes in physical and cognitive function, and absolute muscular strength capacity in this population. In this way, this study will provide preliminary data for the development of standardized, repeatable resistance exercise protocols that will stop the process of ongoing muscle loss and improve metabolism and function in COPD subjects.
Investigators
Marielle PKJ Engelen, PhD
PhD
Texas A&M University
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change in net whole-body protein synthesis
Time Frame: 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes
Change in whole-body protein synthesis rate
Secondary Outcomes
- taurine related metabolism(2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes)
- Body Composition(15 minutes on screening or study day 1)
- arginine related metabolism(2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes)
- Group differences in activity as measured by Physical Activity Scale for the Elderly (PASE)(study day 1)
- glutamate related metabolism(2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes)
- 24 hour diet recall(study day 1)
- appetite questionnaire(study day 1)
- tryptophan related metabolism(2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes)
- leucine related metabolism(2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes)
- changes in skeletal muscle fatigue(on study day 1 and change from day 2 and day 3)
- Group differences in attention and executive functions as measured by Stroop Color-Word Test (SCWT)(on study day 1 and change from day 2 and day 3)
- Group differences in state of mood as measured by the Hospital Anxiety and Depression Scale (HADS)(1 day)
- Group differences in learning and memory as measured by Digit Span(on study day 1 and change from day 2 and day 3)
- Group differences in attention and executive functions as measured by Digit Symbol Modalities Test(on study day 1 and change from day 2 and day 3)