Chronic Obstructive Pulmonary Disorder and Acute Exercise
- Conditions
- Pulmonary Disease, Chronic Obstructive
- Interventions
- Other: stable amino acid infusionOther: acute exercise with amino acid infusionOther: 24-hour post exercise amino acid infusion
- Registration Number
- NCT02780219
- Lead Sponsor
- Texas A&M University
- Brief Summary
For this study a resistance bout will be performed in order to promote the robust response of protein synthesis. Type II muscle fibers often exhibit more atrophy than type I fibers in COPD subjects therefore specifically targeting them in an exercise protocol could have more beneficial outcome for these individuals.
- Detailed Description
In this study, the following hypothesis will be tested: A bout of resistance exercise will affect the acute and 24h response in whole-body protein and amino acid metabolism and cognitive function as compared to baseline values in COPD patients and healthy subjects. To do this, subjects will complete a baseline visit in which they receive stable amino acid tracers. The next day they will complete a one-time resistance exercise with an immediate measurement of the amino acid tracers, and return 24 hours after exercise to repeat amino acid tracer measurements. This project will provide important clinical information on the whole body protein and amino acid metabolic response to acute resistance exercise in elderly subjects with COPD, as well as, the exercise induced changes in physical and cognitive function, and absolute muscular strength capacity in this population. In this way, this study will provide preliminary data for the development of standardized, repeatable resistance exercise protocols that will stop the process of ongoing muscle loss and improve metabolism and function in COPD subjects.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 57
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Healthy acute exercise with amino acid infusion screening visit: body weight and composition by DXA, height, and vital signs will be assessed. study day(s): may include combinations of stable isotope infusions with blood draws, acute exercise, cognition testing Healthy 24-hour post exercise amino acid infusion screening visit: body weight and composition by DXA, height, and vital signs will be assessed. study day(s): may include combinations of stable isotope infusions with blood draws, acute exercise, cognition testing Chronic Obstructive Pulmonary Disorder stable amino acid infusion screening visit: body weight and composition by DXA, height, and vital signs will be assessed. study day(s): may include combinations of stable isotope infusions with blood draws, acute exercise, cognition testing Chronic Obstructive Pulmonary Disorder 24-hour post exercise amino acid infusion screening visit: body weight and composition by DXA, height, and vital signs will be assessed. study day(s): may include combinations of stable isotope infusions with blood draws, acute exercise, cognition testing Healthy stable amino acid infusion screening visit: body weight and composition by DXA, height, and vital signs will be assessed. study day(s): may include combinations of stable isotope infusions with blood draws, acute exercise, cognition testing Chronic Obstructive Pulmonary Disorder acute exercise with amino acid infusion screening visit: body weight and composition by DXA, height, and vital signs will be assessed. study day(s): may include combinations of stable isotope infusions with blood draws, acute exercise, cognition testing
- Primary Outcome Measures
Name Time Method Change in net whole-body protein synthesis 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes Change in whole-body protein synthesis rate
- Secondary Outcome Measures
Name Time Method taurine related metabolism 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes Body Composition 15 minutes on screening or study day 1 Body composition as measured by Dual-Energy X-ray Absorptiometry
arginine related metabolism 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes Group differences in activity as measured by Physical Activity Scale for the Elderly (PASE) study day 1 This questionnaire is intended for use in an elderly population and focuses on 3 types of activities: leisure time activities, household activities and work-related activities.
glutamate related metabolism 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes 24 hour diet recall study day 1 The subject is asked to recall in detail all the food and drink consumed during the 24 hours prior to the test day.
appetite questionnaire study day 1 The subject is asked to rate various aspects of their appetite as relates to overall health
tryptophan related metabolism 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes leucine related metabolism 2, 5, 10, 15, 20, 30, 40, 50, 60, 90, 120, 150, 180, 210 and 240 ± 5 minutes changes in skeletal muscle fatigue on study day 1 and change from day 2 and day 3 kin-com 1-leg test
Group differences in attention and executive functions as measured by Stroop Color-Word Test (SCWT) on study day 1 and change from day 2 and day 3 a word page with words printed in black ink, a color page with blocks printed in color, and a color-word page where the color and the word do not match. The examinee reads the words or names the ink colors as quickly as possible within a time limit. Measures selective attention and inhibitory control. The total time in seconds was reported for each trial.
Group differences in state of mood as measured by the Hospital Anxiety and Depression Scale (HADS) 1 day a fourteen item self-assessment scale. Seven of the items related to anxiety and seven relate to depression. Each item on the questionnaire is scored from 0-3 and this means that a person can score between 0 (no symptoms) and 21 (severe symptoms) for either anxiety or depression.
Group differences in learning and memory as measured by Digit Span on study day 1 and change from day 2 and day 3 recall of numbers in the same order (Digit Forward) and in reverse order (Digit Backward). Measures auditory attention and verbal working memory.
Group differences in attention and executive functions as measured by Digit Symbol Modalities Test on study day 1 and change from day 2 and day 3 Using a legend with nine symbols that correspond to nine different numbers, the examinee is asked to fill in as many blank squares as possible by copying the corresponding number in each box, indexed by a symbol within a 90 sec time limit.
Trial Locations
- Locations (1)
Texas A&M University-CTRAL
🇺🇸College Station, Texas, United States