The MOTS (Medication Overuse Treatment Strategy) Trial
- Conditions
- Migraine
- Interventions
- Other: Discontinuation of Overused MedicationOther: Migraine Prophylactic Therapy Only
- Registration Number
- NCT02764320
- Lead Sponsor
- Mayo Clinic
- Brief Summary
There are two commonly used treatment strategies for treating patients who have chronic migraine with medication overuse. This study will compare the outcomes amongst patients randomized to one of the two treatment strategies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 720
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Discontinuation Discontinuation of Overused Medication Migraine prophylactic therapy will be initiated or optimized with the immediate discontinuation of the overused medication(s) Preventive Therapy Only Migraine Prophylactic Therapy Only Migraine prophylactic therapy will be initiated or optimized without the early discontinuation of the overused medication(s)
- Primary Outcome Measures
Name Time Method Frequency of Moderate to Severe Headache Days 12 weeks Number of days on which a headache lasts for at least 2 hours and at any time peaks at moderate or severe intensity
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (29)
Cleveland Clinic
🇺🇸Cleveland, Ohio, United States
University of Washington
🇺🇸Seattle, Washington, United States
Northern Arizona Healthcare Medical Group
🇺🇸Flagstaff, Arizona, United States
Honor Health Neurology
🇺🇸Scottsdale, Arizona, United States
Mayo Clinic Thunderbird
🇺🇸Scottsdale, Arizona, United States
Keck Medical Center of USC
🇺🇸Los Angeles, California, United States
Blue Sky Neurology
🇺🇸Greenwood Village, Colorado, United States
Memorial Healthcare
🇺🇸Hollywood, Florida, United States
Henry Ford Allegiance Health
🇺🇸Jackson, Michigan, United States
University of Miami Miller School of Medicine
🇺🇸Miami, Florida, United States
Brigham Women's Hospital Headache Clinic
🇺🇸Boston, Massachusetts, United States
Brigham Women's Hospital Neurology Clinic
🇺🇸Boston, Massachusetts, United States
The Headache Center
🇺🇸Ridgeland, Mississippi, United States
Clinvest Research
🇺🇸Springfield, Missouri, United States
University of Cincinnati Headache Center
🇺🇸Dayton, Ohio, United States
University of Cincinnati Neurology
🇺🇸Cincinnati, Ohio, United States
Toledo Clinic Adult Neurology
🇺🇸Toledo, Ohio, United States
Thomas Jefferson University Hospital Headache Center
🇺🇸Philadelphia, Pennsylvania, United States
Preferred Headache Center
🇺🇸Pittsburgh, Pennsylvania, United States
West Virginia University Neurology
🇺🇸Morgantown, West Virginia, United States
University of Utah General Neurology
🇺🇸Salt Lake City, Utah, United States
Mayo Clinic in Arizona Headache Center
🇺🇸Phoenix, Arizona, United States
Mayo Clinic in Arizona Neurology Center
🇺🇸Phoenix, Arizona, United States
University of Colorado Denver Headache Center
🇺🇸Aurora, Colorado, United States
University of Colorado Denver Primary Center
🇺🇸Denver, Colorado, United States
Mayo Clinic Headache Center
🇺🇸Rochester, Minnesota, United States
University of Utah Primary Care
🇺🇸Salt Lake City, Utah, United States
University of Utah Headache Center
🇺🇸Salt Lake City, Utah, United States
Norton Neurology
🇺🇸Louisville, Kentucky, United States