Investigating gastric emptying rate of cow milk by means of MRI in people that either do or do not experience gastrointestinal discomfort after milk ingestion. - Milk DIgestion study (MiDi study)

Wageningen Universiteit0 个研究点目标入组 30 人开始时间: 待定最近更新: 2024年6月11日

适应症

试验速览

暂无简介。

•Drinking cow milk (maximum of 200ml/week for those who declare to not drink habitually and a minimum of 700ml/week for those who declare to drink cow milk habitually)
•Reporting/not reporting GI discomfort after cow milk consumption (depending on study group)
•BMI: 18.5 - 30 kg/m2
•Age: 18 - 60 years
•Healthy (self-reported)
•Need to be willing to be informed about incidental findings of pathology

•Having a history of medical or surgical events related to the GI tract that may give rise to GI complaints
•Medical drug use that influences the GI tract*s normal function, e.g. the motility, pH etc: among others use of proton pump inhibitors, antacids, anti-depressants etc.
•Medical drug use that influence the GI tract*s microbiota: antibiotic use within 1 months prior to the pre-study screenings day
•Mental status that is incompatible with the proper conduct of the study
•Daily use of probiotics
•Weekly use of laxatives
•Lactose intolerance (medically diagnosed or tested with a lactose breath test in screening visit) and cow milk allergy
•Reported unexplained weight loss or weight gain of > 5 kg in the month prior to screening
•Reported slimming or medically prescribed diet
•Reported vegan or macrobiotic life-style
•Alcohol consumption of more than 14 glasses/week
•Smoking more than 4 cigarettes a day
•Not willing to give stool sample during the study
•Being pregnant, having the intention to get pregnant, lactating or being under postmenopausal hormonal treatment
•Not having a general practitioner
•Having a contra-indication to MRI scanning

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