Genetic Susceptibility to Radiation Induced Thyroid Cancer

Completed

• Conditions: Thyroid Neoplasms; Radiation Exposure; Genetic Susceptibility

• Registration Number: NCT04139096
• Lead Sponsor: Institut National de la Santé Et de la Recherche Médicale, France

Brief Summary

Case control on thyroid cancer occuring in a cohort of 7300 subjects treated during their childhood, mostly by radiotherapy, for a skin Angioma at Gustave Roussy, Villejuif France between 1947 and 1973.

This case control study, which is included in a larger european project, aims to investigate the DNA variant interacting with the risk of radiation induced thyroid cancer after irradiation.

The sutdy is planed to include about 30 cases and 30 controls. Matching criteria are date of birth, gender, and age at irradiation.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-09-22
• Study First Submitted: 2019-10-09
• Study First Submitted QC: 2019-10-23
• Study First Posted: 2019-10-25
• Primary Completion: 2021-09-22
• Study Completion: 2021-09-22
• Status Verified: 2025-01
• Last Update Submitted: 2025-01-21
• Last Update Posted: 2025-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Diganosis of thyroid cancer during the followup or selected as a control matched on gender, date of birth and age at skin hemangioma diagnosis.

Exclusion Criteria

No available adress Refusal

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of Differentiated thyroid carcinoma	From hemangioma diagnosis to the end of the followup, in average 45 years after hemangioma diagnosis	Number of differentiated thyroid carcinoma occuring in a cohort of subjects treated for a skin hemangioma during the follow-up

Trial Locations

Locations (1)

Gustae Roussy; 🇫🇷 Villejuif, Val de Marne, France