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Clinical Trials/NCT01208727
NCT01208727
Completed
Not Applicable

The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction

Hospices Civils de Lyon1 site in 1 country44 target enrollmentApril 1, 2009
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ConditionsMyocardial Reperfusion Injury

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Myocardial Reperfusion Injury
Sponsor
Hospices Civils de Lyon
Enrollment
44
Locations
1
Primary Endpoint
Extent of the area of microvascular obstruction
Status
Completed
Last Updated
4 months ago
OverviewInvestigatorsEligibility CriteriaOutcomesSitesSimilar Trials

Overview

Brief Summary

After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

Registry
clinicaltrials.gov
Start Date
April 1, 2009
End Date
March 1, 2011
Last Updated
4 months ago
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Sponsor

Eligibility Criteria

Inclusion Criteria

  • •Patients \> 18 years old,
  • •Male or female,
  • •Presenting first myocardial infarction, with the beginning of pains \< 12 hours,
  • •Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
  • •Artery guilty with TIMI flow = 0

Exclusion Criteria

  • •cardiac arrest before the angioplasty,
  • •Cardiogenic shock
  • •Occlusion of the artery circumflex responsible for the infarction
  • •Magnetic resonance imaging: contre indication

Outcomes

Primary Outcomes

Extent of the area of microvascular obstruction

Time Frame: 5 days

Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group

Secondary Outcomes

  • Size of the myocardial infarction(5 days)

Study Sites (1)

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