NCT01208727已完成不适用
The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Extent of the area of microvascular obstruction
研究概览
简要总结
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients > 18 years old,
- •Male or female,
- •Presenting first myocardial infarction, with the beginning of pains < 12 hours,
- •Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
- •Artery guilty with TIMI flow = 0
排除标准
- •cardiac arrest before the angioplasty,
- •Cardiogenic shock
- •Occlusion of the artery circumflex responsible for the infarction
- •Magnetic resonance imaging: contre indication
结局指标
主要结局
Extent of the area of microvascular obstruction
时间窗: 5 days
Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group
次要结局
- Size of the myocardial infarction(5 days)
研究者
研究点 (1)
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