Post Cond No Reflow
Not Applicable
Completed
- Conditions
- Myocardial Reperfusion Injury
- Interventions
- Procedure: postconditioning
- Registration Number
- NCT01208727
- Lead Sponsor
- Hospices Civils de Lyon
- Brief Summary
After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
Inclusion Criteria
- Patients > 18 years old,
- Male or female,
- Presenting first myocardial infarction, with the beginning of pains < 12 hours,
- Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
- Artery guilty with TIMI flow = 0
Exclusion Criteria
- cardiac arrest before the angioplasty,
- Cardiogenic shock
- Occlusion of the artery circumflex responsible for the infarction
- Magnetic resonance imaging: contre indication
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Intervention postconditioning 22 posconditioned patients
- Primary Outcome Measures
Name Time Method Extent of the area of microvascular obstruction 5 days Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group
- Secondary Outcome Measures
Name Time Method Size of the myocardial infarction 5 days Size of the myocardial infarction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group.
Trial Locations
- Locations (1)
Hospices Civils de Lyon
🇫🇷Lyon, France