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Clinical Trials/NCT01208727
NCT01208727CompletedNot Applicable

The POSTCONDITIONING and THE NO REFLOW Phenomenon in Acute Myocardial Infarction

Hospices Civils de Lyon1 site in 1 country44 target enrollmentStarted: April 1, 2009Last updated:
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Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
44
Locations
1
Primary Endpoint
Extent of the area of microvascular obstruction
Study OverviewStudy DesignEligibility CriteriaOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

After having shown that postconditioning allowed a significant 36% reduction of infarct size as assessed by blood levels of myocardial enzymes in acute myocardial patients, the investigators objective is to assess the effect of postconditioning in acute myocardial infarction (AMI) patients on microvascular obstruction lesions defined by cardiac MRI images.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
None

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Patients > 18 years old,
  • •Male or female,
  • •Presenting first myocardial infarction, with the beginning of pains < 12 hours,
  • •Requiring a revascularisation by primary angioplasty or " rescue " (after failure of thrombolysis) on IVA or RCA (not CA).
  • •Artery guilty with TIMI flow = 0

Exclusion Criteria

  • •cardiac arrest before the angioplasty,
  • •Cardiogenic shock
  • •Occlusion of the artery circumflex responsible for the infarction
  • •Magnetic resonance imaging: contre indication

Outcomes

Primary Outcomes

Extent of the area of microvascular obstruction

Time Frame: 5 days

Extent of the area of microvascular obstruction defined on post-gadolinium CMR images realized 48-72 hours after admission in each group

Secondary Outcomes

  • Size of the myocardial infarction(5 days)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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