Impact of Preoperative Chemotherapy on Complications and Regeneration After Resection of Colorectal Liver Metastases
Completed
- Conditions
- Colorectal Liver Metastases
- Registration Number
- NCT00779272
- Lead Sponsor
- University of Zurich
- Brief Summary
The objective of this study is to evaluate for the first time not only the impact of neoadjuvant chemotherapy on clinical outcome, but also on liver regeneration after liver resection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 184
Inclusion Criteria
- Liver resection due to colorectal liver metastases between 2003 and 2007
Exclusion Criteria
- Incomplete assessment of preoperative chemotherapy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative Complications and liver regeneration 2003- July 2008
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie liver regeneration post-resection in colorectal liver metastases patients treated with neoadjuvant chemotherapy?
How does preoperative chemotherapy compare to standard-of-care in reducing postoperative complications for colorectal liver metastases resection?
Which biomarkers are associated with favorable outcomes following neoadjuvant chemotherapy for colorectal liver metastases resection?
What are the potential adverse events linked to neoadjuvant chemotherapy in colorectal liver metastases patients and how are they managed?
Are there combination therapies or alternative drugs that enhance liver regeneration after resection of colorectal liver metastases compared to chemotherapy alone?
Trial Locations
- Locations (1)
Departement of Visceral and Transplantation Surgery of the University of Zurich
🇨🇭Zurich, Switzerland
Departement of Visceral and Transplantation Surgery of the University of Zurich🇨🇭Zurich, Switzerland