Wolbachia endobacteria in filarial infections - exploring their usefulness as targets for novel chemotherapies that are anti-filarial and improve hydrocele
- Conditions
- ymphatic filariasis (Wuchereria bancrofti)Infections and InfestationsFilariasis
- Registration Number
- ISRCTN19748404
- Lead Sponsor
- Volkswagen Foundation (VolkswagenStiftung) (Germany)
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Male
- Target Recruitment
- 76
1. Men between 18 - 60 years
2. Resident in the village for five years or more
3. Evidence of hydrocele assessed by physical examination and ultrasonography
4. Good general health without any clinical condition requiring long-term medication
5. Minimum body weight 40 kg
1. Evidence of clinically significant neurological, cardiac, pulmonary, hepatic, rheumatological, or renal disease by history, physical examination, and/or laboratory tests
2. Behavioural, cognitive or psychiatric disease that, in the opinion of the investigator, affects the ability of the volunteer to understand and cooperate with the study protocol
3. Laboratory evidence of liver disease (aspartate aminotransferase [AST] alanine aminotransferase [ALT] and/or gamma-glutamyl transferase (gGT) greater than 1.25 times the upper limit of normal of the testing laboratory)
4. Laboratory evidence of renal disease (serum creatinine greater than 1.25 times of the upper limit of normal of the testing laboratory)
5. Other conditions that, in the opinion of the investigator, would jeopardise the safety or rights of a volunteer participating in the trial or would render the subject unable to comply with the protocol
6. Volunteer has abused alcohol or illicit drugs during the past 6 months by history
7. History of severe allergic reaction or anaphylaxis
8. Intolerance to doxycycline
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method