Functional consequences of decreased RNA expression of certain GABA(A) receptor subunits in fragile X patients using Positron Emission Tomography and [11C]flumazenil. - PET-FRAX-GABA

niversity Antwerp0 个研究点开始时间: 2008年9月3日最近更新: 2014年10月7日

适应症

试验速览

暂无简介。

•Males between 18-50 years old, general good health after physical examination and routine laboratory analysis, normal T1 and T2 brain MRI, body weight.
•Males between 16-50 years old, need to be approved by the investigators to undergo a 60 minutes PET imaging study.
•Are the trial subjects under 18? yes
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Controls and patients:
•Drug abuse, hypersensitivity to drugs or flumazenil or benzodiazepines.
•No history of other neurological or psychiatric abnormalities or any other major internal abnormality.
•Medication which interacts with the GABA-system, in particular sleep enhancing medication, is not allowed within two weeks before and after the study, neither
•drinking more than 3 caffein-containing glasses.
•Current smokers (more than 5 sigarettes per day) and smokers who quitted less than three months ago will be excluded.
•Alcohol is prohibited as from 2 days before the beginning of the study.

发起方

niversity Antwerp