The Effects of COX-inhibiting Drugs on Skeletal Muscle Adaptations to Resistance Exercise in Healthy Adults

Phase 2

Completed

• Conditions: Skeletal Muscle Mass Regulation
• Interventions: Drug: Ibuprofen; Drug: Acetylsalicylic acid

• Registration Number: NCT02531451
• Lead Sponsor: Karolinska Institutet

Brief Summary

In this study, healthy human subjects (18-35 yrs) are be randomised to consume 1200 mg ibuprofen or 75 mg acetylsalicylic acid daily during a training period of 8 weeks. During these weeks, subjects perform 2-3 supervised strength training sessions (knee extensions). Before and after training, muscle volume is measured by MRI, and muscle strength is assessed by isokinetic and isoinertial ergometers. Muscle biopsies are obtained from m. vastus lateralis to study gene and protein expression of markers regulating muscle protein turnover and prostaglandin synthesis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-08-19
• Study First Submitted QC: 2015-08-21
• Study First Posted: 2015-08-24
• Study Start: 2015-09
• Status Verified: 2016-06
• Primary Completion: 2016-06
• Study Completion: 2016-06
• Last Update Submitted: 2016-06-27
• Last Update Posted: 2016-06-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 34

Inclusion Criteria

• Considered healthy
• Moderately trained
• 18-35 yrs

Exclusion Criteria

• Cardiovascular disease
• Impaired kidney or liver function
• Lower limb injury
• Pregnancy
• Ulcer or gastrointestinal upsets
• Previous reactions to use of NSAID

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Ibuprofen	Ibuprofen	Resistance exercise 20 sessions during 8 weeks Daily consumption of 1200 mg ibuprofen (400 mg x 3) during 8 weeks
Acetylsalicylic acid	Acetylsalicylic acid	Resistance exercise 20 sessions during 8 weeks Daily consumption of 75 mg acetylsalicylic acid (75 mg x 1) during 8 weeks

Primary Outcome Measures

Name	Time	Method
Change in Quadriceps muscle volume	Baseline and after 8 weeks training	Measured through MRI

Secondary Outcome Measures

Name	Time	Method
Change in muscle protein expression	Baseline, 4 weeks and after 8 weeks training	Through Western Blots
Change in muscle gene expression	Baseline, 4 weeks and after 8 weeks training	Through quantitative PCR and microarray
Change in Quadriceps muscle strength	Baseline and after 8 weeks training	Measured in strength dynamometers

Trial Locations

Locations (1)

Karolinska Institutet; 🇸🇪 Stockholm, Sweden