Effects of ibuprofen on skeletal muscle adaptation to resistance exercise in young healthy adults.
- Conditions
- Human skeletal muscle adaptations to resistance exercise (non-disease related).Therapeutic area: Body processes [G] - Physiological processes [G07]
- Registration Number
- EUCTR2014-004872-47-SE
- Lead Sponsor
- Karolinska Institutet, Department of Laboratory Medicine, Clinical Physiology C1:82,Karolinska Univ. Hosp., Huddinge
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Recruiting
- Sex
- All
- Target Recruitment
- Not specified
men / women age 18-35
Physically active 1-4 hrs per week
Signed informed consent
Deemed healthy after anamnesis and health declaration
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 40
F.1.3 Elderly (>=65 years) no
F.1.3.1 Number of subjects for this age range
Lower leg injury
Sensitivity to any of the prescribed medications
Ulcer or gastrointestinal problems
Liver dysfunction
Autoimmune disease
Kidney disease
Hypertension
Established cardiovascular disease
Anamnesia of substantial bleedings
Consumption of medications that counteracts or act synergistically with the prescribed drugs
Takes part in another research study
Study & Design
- Study Type
- Interventional clinical trial of medicinal product
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Main Objective: To study the effects of Ibuprofen on skeletal muscle adaptations to resistance exercise (see study protocol).;Secondary Objective: Not applicable;Primary end point(s): Muscle volume<br>Muscle strength (force)<br>;Timepoint(s) of evaluation of this end point: Before and after 8 weeks of training
- Secondary Outcome Measures
Name Time Method Secondary end point(s): Muscle gene and protein expression;Timepoint(s) of evaluation of this end point: Before and after acute exercise, as well as before and after training (see protocol)