NCT03456271终止不适用
A Prospective Cohort Study:Forecast Fracture Risk With a Serum Marker of Type 2 Diabetes in Guangzhou Community
Zhujiang Hospital5 个研究点 分布在 1 个国家目标入组 99 人开始时间: 2017年7月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 99
- 试验地点
- 5
- 主要终点
- fracture
研究概览
简要总结
The objective of this study is to find out the biochemical markers which have independent predictive value of fragility fractures risk with Type 2 diabetes in Guangzhou community and evaluate bone strength better and increase the ability of recognizing fracture risk through following-up visits the bone metabolism index like esRAGE-to-pentosidine ratio of the petients with type 2 diabetes and osteoporosis,compared with the classical fracture risk assessment instrument.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •(1) aged 18-65 years; (2) patients were diagnosed with type 2 diabetes based on the definition of diabetes of WHO in 1999.
排除标准
- •type 1 diabetes and other specific types of diabetes;
- •diabetes related acute complications like diabetic ketoacidosis and hyperglycemic hyperosmolar status.
- •had used drugs that is known to have effect on bone(like active vitamin D, bisphosphonate, calcitonin, estrogen receptor modulators, estrogen, thiazolidinediones);
- •suffer from diseases that is known to have effect on bone (hyperthyroidism, hypothyroidism, hyperparathyroidism, hypoparathyroidism,cushing syndrome,chronic renal failure,renal tubular acidosis,osteoporosis after gastrectomy,osteoporosis caused by liver disease,rheumatoid disease,osteoporosis induced by gastrointestinal absorption dysfunction);
- •disuse osteoporosis;
- •cannot be exposure to sunlight due to skin diseases;
- •use glucocorticoids for over 3 months.
结局指标
主要结局
fracture
时间窗: 3 years
the participants happen to fracture
次要结局
未报告次要终点
研究者
研究点 (5)
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