PAV + VENTILATION TRIAL- A Randomised Controlled trial comparing Proportional Assist Ventilation (PAV+) ventilation and pressure support ventilation in patients eligible for spontaneous ventilation.
- Conditions
- Ventilated Patients in the intensive care unit are often difficult to wean and liberate from the ventilator.A new mode of ventilation called PAV+ has advantages over Pressure Support ventilation and may facilitate patients weaning.The study will be a randomised trial comparing the above two modes of ventilation in patients suitable for weaning.Ventilated Patients in the intensive care unit are often difficult to wean and liberate from the ventilator.A new mode of ventilation called PAV+ has advantages over Pressure Support ventilation and may facilitate patients weaning.The study will be a randomised trial comparing the above two modes of ventilation in patients suitable for weaning.Anaesthesiology - Anaesthetics
- Registration Number
- ACTRN12612001097831
- Lead Sponsor
- Peninsula Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
All patients ventilated on Puritan Bennett ventilator with PAV+ software who have been ventilated for at least 48 hours on a mode other than PAV+ or PS, and deemed ready for spontaneous ventilation
Exclusion Criteria
Patients who are not likely to survive 24 hours
Patients admitted for palliation
Patients who are brain dead
Patients with hypoxic brain injury
Patients with a tracheostomy
Patients with neuromuscular injury or disease process
Unable to obtain consent/assent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To evaluate if PAV+ leads to less ventilator time when compared to pressure support ventilation[This timepoint will be assessed from randomisation to completion of mechanical ventilation after the patient is extubated]
- Secondary Outcome Measures
Name Time Method 1.ICU length of stay.<br>This will be assessed from the medical records[This timepoint is from randomisation until time of ICU discharge];2: Hospital length of stay<br>This will be assessed from the medical records[This timepoint is from randomisation until time of hospital discharge];ICU mortality<br>Medical records and patient charts[mortality during ICU stay];hospital mortality<br>medical chart review[mortality whilst still in hospital];re intubation rate<br>Medical records will be reviewed[re intubation within 48 hours extubation<br>Once patients are removed from the ventilator and the endotracheal tube is removed it will be recorded through chart review as to how many patients required to be placed on the ventilator again,having failed extubation and liberation from the ventilator]