Effect of pasteurized Akkermansia muciniphila on maintenance of body weight after a low caloric diet

Recruiting

• Conditions: obesity; insulin resistance; overweight; 10018424

• Registration Number: NL-OMON51753
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 108

Inclusion Criteria

Overweight/obese (BMI >= 28 kg/m2 < 40 kg/m2) men and women

Exclusion Criteria

- diabetes mellitus
- gastroenterological diseases or major abdominal surgery (allowed i.e.:
appendectomy, cholecystectomy)
- lactose intolerance and other digestive disorders
- cardiovascular disease, cancer, liver or kidney malfunction (determined based
on ALAT and creatinine levels,
respectively)
- disease with a life expectancy shorter than 5 years
- abuse of products (alcohol consumption > 15 units/week, or any drugs)
- excessive nicotine use defined as >20 cigarettes per day
- plans to lose weight or follow a hypocaloric diet
- regular supplement of pre- or probiotic products
- intensive exercise more than three hours a week
- Use of any medication that influences glucose or fat metabolism, like
lipidlowering-drugs (e.g. PPAR γ or PPARa (fibrates) agonists),
glucose-lowering agents (including allsulfonylureas, biguanides, a-glucosidase
inhibitors, thiazolidinediones, repaglinide, nateglinide and insulin),
inflammation (e.g. anti-inflammatory or immunosuppressive drugs) and
anti-oxidants;
- use of laxation products in the last three months or during the study period-
Suikerziekte heeft;
- Pregnancy and lactation
-vegan

Study & Design

• Study Type: Interventional
• Study Design: Not specified