Contrast Echocardiography in Non-ST Elevation Myocardial Infarction

Completed

• Conditions: Non-ST-Elevation Myocardial Infarction
• Interventions: Other: Perflutren Lipid Microsphere ultrasound contrast

• Registration Number: NCT01122069
• Lead Sponsor: University of Bergen

Brief Summary

In patients with acute myocardial infarction, treatment logistics are primarily defined based upon ST segment shift in the electrocardiogram. While patients with ST elevation (STEMI) are forwarded to immediate coronary angiography and percutaneous coronary intervention, patients without ST elevation (NSTEMI) are initially medically treated and recommended coronary angiography within 48-72 hours.

Early invasive treatment has been found cost-effective in intermediate and high-risk NSTEMI patients and current guidelines recommend use of the Thrombolysis in Myocardial Infarction (TIMI) risk score to identify patients who will benefit from early intervention due to high risk of new infraction and cardiovascular death. However, new research has suggested that TIMI risk score may not always identify patients with severe angiographic disease.

The purpose of this study was to assess if contrast echocardiography could be used to identify NSTEMI patients with angiographically severe disease independent of their TIMI risk score.

Detailed Description

Not available

Study Timeline

• Status Verified: 2007-12
• Study Start: 2008-03
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Study First Submitted: 2010-05-10
• Study First Submitted QC: 2010-05-11
• Last Update Submitted: 2010-05-11
• Study First Posted: 2010-05-12
• Last Update Posted: 2010-05-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 110

Inclusion Criteria

• acute non-ST elevation myocardial infarction

Exclusion Criteria

• hemodynamic unstable
• mechanical prosthetic heart valve
• severly reduced pulmonary function

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Contrast echocardiography	Perflutren Lipid Microsphere ultrasound contrast	110 patients with acute non-ST elevation myocardial infarct were examined with contrast echocardiography prior to coronary angiography.

Trial Locations

Locations (1)

Department of Heart Disease, Haukeland University Hospital; 🇳🇴 Bergen, Norway