COMPARITIVE STUDY BETWEEN DEXMEDETOMEDINE AND BUPRENORPHINE AS AN ADJUVANT TO ROPIVACAINE 0.5% IN ULTRASOUND GUIDED SUPRACLAVICULAR BRACHIAL PLEXUS BLOCK FOR UPPER LIMB ORTHOPEDIC SURGERIES

Not yet recruiting

• Conditions: Fracture of upper end of radius, (2) ICD-10 Condition: S520||Fracture of upper end of ulna,

• Registration Number: CTRI/2021/10/037274
• Lead Sponsor: Sanjay Gandhi Institute Of Trauma And Orthopedics

Brief Summary

.Supraclavicular block is a regional anaesthetic technique used as an alternative or adjunct to general anesthesia or used for postoperative pain control for upper extremity surgeries (mid-humerus through the hand).

Various adjuvants have been added to local anesthetics to increase the efficacy and duration of blocks,minimizing systemic adverse effects along with a reduction in the total dose of local anesthetic used.

Dexmedetomidine, a potent α2 adrenocepter agonist ,has been reported to improve the quality of intrathecal and epidural anesthesia.(1,2,3) Its use in peripheral nerve blocks has recently been described.

Buprenorphine is lipophilic opioid with high molecular weight and having high affinity for μ receptors, has a longer duration of action,and is easily available, cost-effective and hence selected for this study

Ropivacaine has a long duration of action, with similar pharmacology to bupivacaine but a wider safety margin

In this study, we will investigate whether adding dexmedetomidine  or buprenorphine to 0.5%ropivacaine for supraclavicular brachial plexus block would affect the sensory and motor blocks and duration of analgesia

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2021-10-10
• Study Start: 2021-10-21

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 90

Inclusion Criteria

Patients aged between 18 to 60 years admitted for elective upperlimb orthopaedic surgeries in Sanjay Gandhi Institute Of Trauma And Orthopaedics,Bengaluru.

Exclusion Criteria

History of neurological, psychiatric, neuromuscular,alcoholism or drug abuse and patients receiving adrenoceptor agonist or antagonist therapy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
time of onset of sensory block and duration of analgesia	1 day

Secondary Outcome Measures

Name	Time	Method
any adverse effects	1 day

Trial Locations

Locations (1)

Major operation theater Sanjay Gandhi Institute of Trauma and Orthopedics; 🇮🇳 Bangalore, KARNATAKA, India

Major operation theater Sanjay Gandhi Institute of Trauma and Orthopedics

🇮🇳Bangalore, KARNATAKA, India

Dr Sangeetha C

Principal investigator

9886623479

sangudaya.sd@gmail.com