Comparison of two different doses of drug for sedation in patients undergoing operation under spinal anaesthesia

Phase 2

Not yet recruiting

Brief Summary: Subarachnoidblock is a widely used regional anaesthetic technique particularlyadvantageous for lower abdominal surgeries (l).Many spinal and epidural anaesthetic failed because of inadequate intravenous sedation and anxiolysis ratherthan technically flawed blocks .As unsedated patient may be apprehensive anduncooperative to the surgical procedure inspite of having adequate levels ofanalgesia by spinal anesthesia . Patients are often reluctant to remain awake during a procedure and the requirement to maintain uncomfortablepositioning throughout the surgery oflong duration can cause spontaneous movements which may interfere with thesurgical procedure. Therefore, provision of adequate sedation is important if the advantages of spinal anaesthesiato be fully appreciated.Theliterature review has few studies to asessthe efficacy of intravenous ( IV )dexmedetomidine infusion on spinalanesthesia block characteristics however , there are no studies till date to asessits efficacy on sedation or to evaluate the ideal dose of IV dexmedetomineinfusion for sedation .Hencethis study has been formulated to compare two different doses of dexmedetomidine infusion to provide continuous sedation in patients undergoinglower abdominal general surgical procedures under spinal anesthesia

Recruitment & Eligibility

Inclusion Criteria

1)American society of anaesthesiology (ASA) physical status 1 and 2 patients.

Exclusion Criteria

1)Patients undergoing laparoscopic surgeries.
2)Patients who have arrhythmia , heart failure , liver failure , renal failure or bleeding tendencies.
3)Patients with heart blocks , on calcium channel blockers and betablockers.
4)Allergic to study drug and local anesthetic.
5)Those who are not willing to participate in the study.

Primary Outcome Measures

Name	Time	Method
To evaluate the effect of intravenous Dexmedetomidine infusion on sedation and duration of analgesia.	For intraoperative period and for 24 hours postoperatively.

Secondary Outcome Measures

Name	Time	Method
To evaluate hemodynamic changes and side effects of study drug if any.	For intraoperative period and for 24 hours postoperatively

Locations (1): Sapthagiri institute of medical sciences and research center
🇮🇳
Bangalore, KARNATAKA, India
Sapthagiri institute of medical sciences and research center
🇮🇳Bangalore, KARNATAKA, India
Dr Renuka R
Principal investigator
8618633196
amulyapreyakumar74@gmail.com