CTRI/2020/08/027117
Recruiting
Phase 2
Focal Radiotherapy Plus Low-Dose Craniospinal Irradiation Followed By Adjuvant Chemotherapy in WNT Subgroup Medulloblastoma(FOR-WNT 2 STUDY) - (FOR-WNT 2 STUDY)
Overview
- Phase
- Phase 2
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Tata Memorial Hospital
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age more than 3 years and less than 16 years.
- •Newly diagnosed WNT pathway medulloblastoma.
- •Post\-surgery residual disease less than 1\.5 cm2 on post\-operative MRI brain.
- •No evidence of metastatic disease in the brain, spine or cerebral spinal fluid (CSF) assessed by MRI of the brain/spine and lumbar puncture for CSF cytology.
- •Fit for initiation of adjuvant treatment within 6\-weeks of surgery
Exclusion Criteria
- •Age Less than 3 and more than 16 years.
- •Molecular subgroup other than WNT pathway.
- •Post\-surgery residual disease more than 1\.5cm2 on post\-operative imaging.
- •Evidence of any metastatic disease in the brain, spine or CSF.
- •Previous history of radiotherapy or chemotherapy prior to study enrollment.
- •Not fit for initiation of adjuvant treatment within 6 weeks of surgery.
- •Not willing for consent/assent.
Outcomes
Primary Outcomes
Not specified
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