Focal Radiation and low dose skull and spine irradiation followed by chemotherapy for WNT subgroup medulloblastoma
- Conditions
- Health Condition 1: G938- Other specified disorders of brain
- Registration Number
- CTRI/2020/08/027117
- Lead Sponsor
- Tata Memorial Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Age more than 3 years and less than 16 years.
Newly diagnosed WNT pathway medulloblastoma.
Post-surgery residual disease less than 1.5 cm2 on post-operative MRI brain.
No evidence of metastatic disease in the brain, spine or cerebral spinal fluid (CSF) assessed by MRI of the brain/spine and lumbar puncture for CSF cytology.
Fit for initiation of adjuvant treatment within 6-weeks of surgery
Age Less than 3 and more than 16 years.
Molecular subgroup other than WNT pathway.
Post-surgery residual disease more than 1.5cm2 on post-operative imaging.
Evidence of any metastatic disease in the brain, spine or CSF.
Previous history of radiotherapy or chemotherapy prior to study enrollment.
Not fit for initiation of adjuvant treatment within 6 weeks of surgery.
Not willing for consent/assent.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method