Population-based Investigation of Aneurysm Incidence

Not Applicable

Completed

• Conditions: Intracranial Aneurysm
• Interventions: Diagnostic Test: blood test

• Registration Number: NCT06412783
• Lead Sponsor: Beijing Tiantan Hospital

Brief Summary

Most intracranial aneurysms are found accidentally in neurovascular imaging. And these inspection methods are limited by the problems of instrument fixation, radiation, time-consuming, contrast agent toxicity and so on. At present, blood test is an ideal alternative method for early diagnosis. Compared with imaging examination, it is economical, general screening and convenient. Blood test is simple to operate, easy to be accepted by patients, and less invasive. Early screening of aneurysms can be performed.

Detailed Description

Not available

Study Timeline

• Study Start: 2023-10-01
• Study First Submitted: 2023-11-12
• Status Verified: 2024-05
• Study First Submitted QC: 2024-05-13
• Study First Posted: 2024-05-14
• Primary Completion: 2024-11-30
• Study Completion: 2025-02-28
• Last Update Submitted: 2025-05-13
• Last Update Posted: 2025-05-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 4711

Inclusion Criteria

• Age 35-75
• Individuals with normal cognitive and communication abilities
• No serious complications, such as uncontrolled hypertension, diabetes or other chronic diseases that may affect the test results.
• Basic blood test is normal or close to normal range.

Exclusion Criteria

• Pregnancy
• Severe heart disease, renal insufficiency, liver dysfunction and other major diseases.
• In the past 6 months, there were strokes, or other types of intracranial tumors, infections and other diseases that may affect the screening results.
• There are metal implants, including dentures, pacemakers, etc.
• Using or recently used drugs that may affect blood biomarkers ( such as anticoagulant drugs, immunosuppressive agents, etc. ).
• There are serious mental illness or cognitive dysfunction, such as claustrophobia, unable to cooperate with the completion of the test.
• It is currently participating in other clinical trials or has participated in other clinical trials in the past 3 months.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
blood test group	blood test	-

Primary Outcome Measures

Name	Time	Method
Specific markers are detected	1hours after blood collection	oleic acid, arachidonic acid, docasa-hexaenoic acid, interleukin 1β， interleukin 1ra, tumor necrosis factors, SOD3, PPIA, S100A8, S100A9, MPO, APOA4, THBS1.

Trial Locations

Locations (1)

Capital Medical University Affiliated Beijing Tiantan Hospital; 🇨🇳 Beijing, Beijing, China