Intracranial aneurysms: searching for markers of instability and risk of rupture
Completed
- Conditions
- intracranial aneurysmsvascular abnormality in the head10002363
- Registration Number
- NL-OMON38220
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 210
Inclusion Criteria
Patients of age 18 years or older with a ruptured or unruptured intracranial aneurysm who need surgical clipping (N=70) or endovascular coiling (N=70) to treat the aneurysm.;For the control group: patients of age 16 years or older with therapy resistant epilepsy who need epilepsy surgery with brain resection (N=70).
Exclusion Criteria
Patients with a ruptured or unruptured intracranial aneurysm who will not undergo treatment of the aneurysm or who are under the age of 18 years.;For the control group: Patients with therapy resistant epilepsy who need epilepsy surgery with brain resection who are under the age of 16 years or who have an intracranial aneurysm or other vascular malformation.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>1. differences in gene expression of ruptured and unruptured aneurysmal<br /><br>biopsies and control tissue<br /><br>2. changes in cell types or vessel wall components of ruptured and unruptured<br /><br>aneurysmal biopsies and control tissue<br /><br>3. correlation of the expression of proteins of interest with the size/stage of<br /><br>development of the aneurysm.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>