Biological and biochemical markers of aneurysm wall degradation; towards non-invasive wall strength analysis.

• Conditions: Abdominal Aortic dilatation; 10002363; arterial bulge; 10003184

• Registration Number: NL-OMON30536
• Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

1. patients scheduled for conventional repair of an asymptomatic or symptomatic (non-ruptured) aneurysm.
2. Informed consent
3. Preoperative CT (computer tomography)

Exclusion Criteria

1. Patients with a ruptured abdominal aortic aneurysm
2. Contraindication for MR imaging (metallic implants, claustrophobia).
3. Prior aortic surgery
4. Severe cardiac comorbidity (congestic heart failure/coronary artery disease)

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Aneurysm wall tensile strength (N/mm).<br /><br>2. Concentration of biodegrading enzymes in the aneurysm wall (arbitrary units<br /><br>per milligram proteins).<br /><br>3. The presence of specific glucosaminoglycans in the AAA wall and in patients<br /><br>blood and urine.<br /><br>4. Drop in relative MR signal intensity on USPIO enhanced MR imaging<br /><br>(macrophage detection).<br /><br>5. Histological presence of macrophages (field count). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p> 1. Aneurysm diameter</p><br>