Biomarkers of Aneurysm Wall Strength
- Conditions
- Abdominal Aortic Aneurysm
- Registration Number
- NCT00740740
- Lead Sponsor
- Radboud University Medical Center
- Brief Summary
The purpose of this study is to identify possible in vivo biochemical and biological markers related to aortic wall strength.
- Detailed Description
Rupture of an Abdominal Aortic Aneurysm (AAA) is potentially lethal. prophylactic surgical repair is therefore warranted when the risk of rupture exceeds the risk of complications following surgery. Aneurysm rupture occurs when the forces (stress) acting on the aneurysm wall surpass aneurysm wall strength. Information on both wall stress and strength might therefore improve rupture risk assessment and patient selection for prophylactic repair. Although aneurysm wall stress calculations are possible, no in vivo method exists to determine aneurysm wall strength. This study was designed to identify possible biomarkers of aneurysm wall strength
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
- Patient scheduled for transabdominal aortic surgery
- Patient characteristics and aneurysm anatomy suitable for endovascular repair
- Previous aortic surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Aneurysm wall strength Post-operative
- Secondary Outcome Measures
Name Time Method Extra Cellular Matrix components (Glucoaminoglycans) post-operative Biochemical blood analysis post-operative MMP content post-operative Degree of inflammation Post-operative
Trial Locations
- Locations (2)
Radboud University Nijmegen Medical Center
🇳🇱Nijmegen, Gelderland, Netherlands
Alysis Zorggroep, Rijnstate Hospital
🇳🇱Arnhem, Gelderland, Netherlands