Biological and biochemical markers of aneurysm wall degradation; towards non-invasive wall strength analysis. - Biomarkers for aneurysm wall strength

• Conditions: Abdominal aortic aneurysms. Biomarkers related to diminished aneurysm wall strength.; MedDRA version: 9.1Level: LLTClassification code 10000051Term: Abdominal aneurysm

• Registration Number: EUCTR2007-000214-37-NL
• Lead Sponsor: MC St Radboud

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2007-04-17
• Last Update Posted: 19 March 2012

Recruitment & Eligibility

• Status: Authorised-recruitment may be ongoing or finished
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

· Forty patients scheduled for conventional repair of an asymptomatic or
symptomatic (non-ruptured) aneurysm.
· Informed consent
· Clinical condition allows MR imaging (USPIO group)
· Preoperative CT (computer tomography)

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

· Ruptured aneurysm
· Patient characteristics and aneurysm anatomy suitable for endovascular repair
· Contraindication for MR imaging like metallic implants or claustrophobia
(USPIO group).
· Previous aortic aneurysm surgery
· Severe cardiac co-morbidity (e.g. Chronic Heart Failure, Caronary artery disease).

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified