Carotid Intima-Media Thickness and Plaque Assessment Findings in Subjects Undergoing Stress Echocardiography For Risk Stratification
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- Mayo Clinic
- 入组人数
- 73
- 试验地点
- 1
- 主要终点
- % Patients w/ Abnormal IMT vs. % Patients w/ Positive Ischemia on Stress Echocardiogram
研究概览
简要总结
The purpose of this research study is to determine if carotid artery ultrasound scanning can provide additional information for determining cardiovascular risk in patients.
Patients who agree to participate wil undergo non-invasive carotid intima-media thickness (CIMT) measurement and plaque assessment. Findings of CIMT will be compared to results of patient standard of care stress echocardiogram (SE) and of diastolic function.
We hypothesize tht 1) in patients undergoing SE for inappropriate or uncertain indications, CIMT and plaque assessment will provide useful risk stratification beyond use of traditional risk factors; 2) CIMT findings will correlate with results of SE in terms of exercise capacity and 3) Exercise capacity will correlate with diastolic function.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Asymptomatic
- •No prior cardiac history (MI, PTCA, CABG, angina)
- •No peripheral vascular disease
- •No history of stroke or TIA
- •Statins, antihypertensives, ASA treatment OK
排除标准
- •History of CAD, CABG, PTCA, coronary or peripheral stenting
- •History of stroke/TIA/peripheral vascular disease
- •Inability to exercise on the treadmill
- •Unwilling/unable to sign informed consent
- •History of neck radiation or neck surgery or inability to obtain neck images
- •End stage renal disease
- •Preoperative evaluation
- •History of chest pain
结局指标
主要结局
% Patients w/ Abnormal IMT vs. % Patients w/ Positive Ischemia on Stress Echocardiogram
时间窗: Baseline
We are comparing the % of patients with abnormal IMT defined as presence of plaque (= or \>1.5mm) or CIMT \>75% percentile for age, race, and gender compared to % of patients with positive ischemia on stress echocardiogram as defined by a new wall motion abnormality on echocardiogram with stress.
次要结局
未报告次要终点