NCT04958005CompletedNot Applicable
Evaluation of Salivary Interleukin-32, Interleukin-10, Interleukin-6 and Tumor Necrosis Factor-alpha Levels in Children With Early Childhood Caries.
Aydin Adnan Menderes University1 site in 1 country58 target enrollmentStarted: July 1, 2021Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 58
- Locations
- 1
- Primary Endpoint
- IL-32
Study Overview
Brief Summary
This study aimed to evaluate the levels of interleukin 10, interleukin 6, interleukin 32 and tumor necrosis factor-alpha (TNF-α) in saliva of children with early childhood caries.
Detailed Description
Fifty six children ( 28 with early childhood caries and 28 without early childhood caries ; age range 3-6 years) will be recruited for the study. Probing pocket depth (PPD), gingival index (GI) and plaque index (PI) will be recorded and saliva samples will be collected. Interleukin-32, Interleukin-10, Interleukin-6 and TNF-α will be analyzed in saliva samples by ELISA.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Cross Sectional
Eligibility Criteria
- Ages
- 3 Years to 70 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Children with untreated early chilhood caries
- •Age between 3 and 6 years
Exclusion Criteria
- •Having a systemic problem or mental retardation
- •Children with treated caries
Outcomes
Primary Outcomes
IL-32
Time Frame: Baseline
Interleukin- 32 level
IL-10
Time Frame: Baseline
Interleukin- 10 level
Secondary Outcomes
- Tnf-Alpha(Baseline)
- IL-6(Baseline)
Investigators
Sultan KELES
Assoc.Prof.Dr.
Aydin Adnan Menderes University
Study Sites (1)
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