Randomized Controlled Pilot Study to Evaluate Fasting-mimicking Diet in Patients Receiving Chemo-immunotherapy for Treatment of Metastatic Non-small Cell Lung Cancer
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 6
- 主要终点
- Proportion of the patients who can finish the FMD without serious adverse events
研究概览
简要总结
The purpose of this study is to learn the effects of fasting on cancer cells while you get maintenance treatment.
详细描述
Cancer cells use an increased supply of glucose to make energy and do not have protection against fasting that normal cells do. Because of this, researchers would like to study how fasting may help chemotherapy target cancer cells instead of normal cells. Initial studies suggest that fasting may decrease the side effects of chemotherapy and increase the chances of your cancer responding to the chemotherapy. Patient populations will have non-small cell lung cancer in which chemo-immunotherapy with carboplatin/pemetrexed and pembrolizumab have been recommended to treat the cancer as part of standard care.
Primary Objective 1. To determine the feasibility and compliance of administering a fasting-mimicking diet (FMD) in patients with advanced NSCLC receiving maintenance therapy
Secondary Objectives
- To assess a patient's willingness to fast for second cycle
Correlative Objectives
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •≥ 18 years at the time of informed consent
- •Ability to provide written informed consent and HIPAA authorization
- •Eastern cooperative group (ECOG) performance status of 0 to 2
- •Histologically confirmed Non-Small Cell Lung Cancer (NSCLC) and have advanced disease.
- •Patients should be on maintenance therapy for advanced NSCLC as defined as treatment with single agent immunotherapy, single agent chemotherapy plus immunotherapy or single agent molecularly targeted therapy for a minimum of 2 months prior to study entry
- •If a patient is on a treatment that lowers their ANC, their ANC has to be ≥ 1500 on the first day of fasting
排除标准
- •Self-reported weight loss of > 10% in the 6 weeks prior to study entry
- •History of diabetes mellitus or patients with a known recent elevated A1c > 6
- •History of symptomatic hypoglycemia
- •Prior therapies with inhibitors of IGF-1 such as
- •Picropodophyllin
- •Concurrent use of somatostatin
- •Concurrent use of immunosuppressive medications including sirolimus, tacrolimus, mycophenolate mofetil, azathioprine, prednisone, dexamethasone, or cyclosporine
- •Significant food allergies (screening checklist in Appendix 3) which would make the subject unable to consume the food provided
- •History or current evidence of any medical or psychiatric condition, therapy that may confound the results of the trial, interfere with the subject's participation for the full duration of the trial, or is not in the best interest of the participating subject as deemed by the treating investigator.
- •Pregnant or lactating females are not eligible.
结局指标
主要结局
Proportion of the patients who can finish the FMD without serious adverse events
时间窗: Between screening/baseline (28 to 4 days before Cycle 1 Day 1) and Cycle 1 Day 21 or 28 (Cylces last 21 or 28 days, based on treatment)
To assess feasibility, compliance will be measured by a daily log
次要结局
未报告次要终点
研究者
Shadia Jalal
Associate Professor of Clinical Medicine
Indiana University