Pharmacokinetics of Curcumin in Healthy Volunteers

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT00181662
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

This study looks to describe the pharmacokinetics of curcumin delivered as a single oral dose in healthy female volunteers. The impact of piperine and silybin on the pharmacokinetics of curcumin is also studied.

Detailed Description

Healthy volunteers are seen on three separate visits and receive 4 gm of curcumin as a single oral dose either alone or with piperine or with silybin. Serial timed blood draws then are collected for pharmacokinetic analysis.

Study Timeline

• Study Start: 2005-08
• Study First Submitted: 2005-09-12
• Study First Submitted QC: 2005-09-12
• Study First Posted: 2005-09-16
• Primary Completion: 2007-10-17
• Study Completion: 2007-10-17
• Status Verified: 2020-10
• Last Update Submitted: 2020-10-30
• Last Update Posted: 2020-11-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 6

Inclusion Criteria

• Healthy volunteer
• On no medications except for birth control pills
• Signed informed consent

Exclusion Criteria

• Pregnant
• Comorbid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Curcumin pharmacology

Secondary Outcome Measures

Name	Time	Method
Interactions between piperine and curcumin
Interactions between silybin and curcumin

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States