Interaktion Von Ausgewählten Inflammationsparametern, Geschmackswahrnehmung Und Geschmackspräferenzen in Abhängigkeit Von Physischer Aktivität Und Körperzusammensetzung
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- Body composition
研究概览
简要总结
The aim of this study is to investigate whether differences in taste perception and preference behavior can be attributed to inflammatory processes induced by physical activity. The focus will be on sweet taste and the perception of fat. A non-invasive, observational study design will be used.
详细描述
This study adresses the question of whether there is a connection between low-grade inflammation caused by physical activity and a change in taste perception and preference for the sweet taste. The taste perception, preference behavior and inflammation in athletic and healthy non-athletic subjects using an observational study design is investigated.
The hypothesis is that athletic test subjects, compared to healthy, physically inactive subjects, show increased inflammation values, in the range of a low-grade inflammation, and that this results in a lower sensitivity and increased preference for sweet taste.
The primary parameters to be investigated are a possible correlation between the level of physical activity physical activity or body composition and the recognition threshold for the sweet taste as well as the preference. In addition, a correlation between the concentration of TNF-α and IL-6 in saliva sweet recognition threshold and sweet preference will be investigated.
Secondary parameters to be analyzed are the preference for fatty substances, the perception threshold for the perception threshold for the fatty taste, taste receptors in saliva for the sweet and fatty taste, the concentration of 8-epi-PGF2α in the urine as a marker for oxidative stress, and the number of fungiform papillae on the tongue are determined.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 45 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-smoking
- •normal taste and smell perception
排除标准
- •pregnancy or breast-feeding
- •regular smokers
- •regular intake of medication
- •metabolic diseases that require drug therapy
- •ageusia or anosmia
- •alcohol or drug addiction
- •intake of antibiotics within the past 2 months
- •vegan diet
- •viral or bacterial infection wihtin the past three weeks
结局指标
主要结局
Body composition
时间窗: day 1
body fat percentage
Low-grade inflammation
时间窗: day 1
Concentration of interleukin 6 and tumor necrosis factor alpha in unstimulated saliva
Taste sensitivity
时间窗: day 1
detection threshold for sweet and fatty taste analysed using a 3-AFC test
Taste preference
时间窗: day 1
preference for sweet and fatty taste analyzed by means of a Food Frequency Questionnaire and food choices from a standardized breakfast
次要结局
- fungiform papillae density(day 1)
- Oxidative Stress(day 1)
研究者
Barbara Lieder
Professor and Vice Chair Department of Physiological Chemistry
University of Vienna
