Monitoring of stress due to fluid shifts and reduced cerebral clearance in patients in surgery-related Trendelenburg positioning.
Not Applicable
- Conditions
- Patients requiring radical prostatectomy who are positioned in Trendelenburg position for several hours due to surgery.
- Registration Number
- DRKS00031041
- Lead Sponsor
- MU Klinikum, Klinik für Anästhesiologie
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Male
- Target Recruitment
- 50
Inclusion Criteria
Patient is able to give consent and available written informed consent.
-planned radical prostatectomy
Exclusion Criteria
- Subjects who are not capable of giving consent
- missing signed informed consent
- Known neurological disease with or without elevated intracranial pressure.
- Known underlying psychiatric disease with or without permanent medication
- Eye disease (e.g. glaucoma)
- Severe lung disease
- Immunosuppressive medication
- Participation in another research project or clinical trial that conflicts with this study
- Known severe autoimmune disease resulting in classification of ASA Group III or higher
- Known alcohol, drug or medication abuse
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Concentration of neurofilament light chain (NFL) in blood perioperatively (preoperative, surgery day of surgery, postoperative day 1, day 3 and on the day before discharge).
- Secondary Outcome Measures
Name Time Method