A Randomized Comparative Clinical Study To Evaluate The Efficacy Of Amrutharajanyadi Kashaya And Standard Care In Childhood Urticaria

Urticaria is a dermal vascular reaction of the skin characterized by the appearance of itchy wheals, which are elevated (oedematous), pale or erythematous, transient and evanescent plaque lesions. The clinical picture of urticaria closely resemble with that of Sheetapitta described in Ayurveda classics.  Sheetapitta is characterized by skin lesions which resembles Varathidamshta samsthana shotha (Appearance of swelling resembling as that of bite of wasp), Kandu(itching), Bahula Thoda (excessive pricking pain), Vidaha (burning sensation) associated with chardi (vomitting) and jwara(fever). Vata is predominant dosha in Sheetapitta. Although many cases of urticaria are self limiting, in case of chronic and recurrent conditions, parents generally sought treatment. To combat the hypersensitivity reaction in the body, administration of immunomodulatory drugs will be helpful especially in children who are having under developed immunity.

The selected trial drug, Amrutha Rajanyadi Kashaya contains drugs having proven immunomodulatory activity which will be helpful in managing the condition in children effectively. The primary objectives of the study are to study the effect of Amrutharajanyadi Kashaya and standard care in the management of childhood Urticaria separately and to to compare the effect in both the groups. The secondary objective is to evaluate and compare the effect of Amrutharajanyadi Kashaya and standard care on quality-of-life parameters in children suffering from Urticaria. The study hypothesize that Amrutharajanyadi Kashaya is as effective as standard care in managing childhood urticaria.