Narcolepsy Nightmare Study

Not Applicable

Completed

• Conditions: Narcolepsy Without Cataplexy; Narcolepsy With Cataplexy; Narcolepsy Type 1; Narcolepsy; Narcolepsy Type 2
• Interventions: Behavioral: Imagery rehearsal therapy; Behavioral: Targeted dream control

• Registration Number: NCT05709873
• Lead Sponsor: Northwestern University

Brief Summary

The goal of this clinical trial is to test two behavioral treatments for nightmares in adults with narcolepsy. The main questions it aims to answer are:

* Is imagery rehearsal therapy (IRT) effective for narcolepsy-related nightmares?

* Does adding targeted dream control (TDC) to IRT make it more effective?

Participants will be randomized to one of two treatment groups and will be asked to:

* Complete a daily log of sleep symptoms for up to 13 weeks.

* Attend 7 sessions of treatment.

* Complete questionnaires before and after treatment.

* Go to the research lab in Evanston, IL to complete a sleep study during a daytime nap (Chicago area residents only).

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-01-24
• Study First Submitted QC: 2023-01-24
• Study First Posted: 2023-02-02
• Study Start: 2023-02-22
• Primary Completion: 2024-04-30
• Study Completion: 2024-04-30
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-10
• Last Update Posted: 2024-06-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 7

Inclusion Criteria

Not provided

Exclusion Criteria

• History of a neurological disorder that might alter EEG
• Currently engaged in sleep- or trauma-focused psychotherapy
• Previous behavioral treatment for nightmares
• Medical, psychiatric, or cognitive condition which would interfere with ability to engage in the treatment
• Untreated sleep apnea (AHI ≥ 5)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Imagery rehearsal therapy and targeted dream control (IRT+TDC)	Imagery rehearsal therapy	Participants randomized to this group will receive 7 sessions of IRT+TDC.
Imagery rehearsal therapy (IRT)	Imagery rehearsal therapy	Participants randomized to this group will receive 7 sessions of IRT.
Imagery rehearsal therapy and targeted dream control (IRT+TDC)	Targeted dream control	Participants randomized to this group will receive 7 sessions of IRT+TDC.

Primary Outcome Measures

Name	Time	Method
Daily diary	Duration of study (11-13 weeks)	Nightmare severity/frequency

Trial Locations

Locations (1)

Northwestern University; 🇺🇸 Chicago, Illinois, United States