Rhythm control of AF in patients with acute stroke

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 300

Inclusion Criteria

1. Atrial fibrillation patients aged 20 to 80
2. Acute cerebral infarction or transient ischemic attack, which is estimated to be cardiac embolism within seven days of the stroke.
3. Left atrium size of an atrial fibrillation patient < 55mm
4. Patients capable of anticoagulation and antiarrhythmic drugs
5. NIHSS(National Institutes of Health Stroke Scale) score = 12 and the neurological condition is capable of outpatient follow up.

Exclusion Criteria

1. Patient with significant hemorrhagic transformation
2. cerebral hemispheres infarction or cerebellum infarction patient(The size of cerebral infarction is more than 1/3 of the MCA(middle cerebral artery), 1/2 of the ACA(anterior cerebral artery), 1/2 of the PCA(posterior cerebral artery), and 1/2 of the cerebellum)
3. patient with active internal bleeding
4. Impossible to anticoagulation or antiarrhythmic drug
5. valvular atrial fibrillation (Mitral stenosis > grade II, Mechanical valve, Mitral valve replacement)
6. LVEF(left ventricular ejection fraction ) < 30%
7. Structural heart disease requiring surgical correction
8. The patients who had been performed catheter ablation of atrial fibrillation or heart surgery
9. Patients who are already on antiarrhythmic drug for rhythm control
10. Patients with severe medical disease
11. Expected survival < 1 year
12. Patients with invasive surgery or surgery scheduled
13. Severe alcoholics, drug addiction
14. A patient against MRI(magnetic resonance imaging) scanning
15. pregnancy
16. A patient participating in another study
17. Patients judged to be unfit for clinical trial by researchers' judgment

Study & Design

Study Type: Interventional Study

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Major cardiovascular or overall death, such as cerebral infarction, myocardial infarction, sudden death, and death, that occurred during follow-up.

Secondary Outcome Measures

Name	Time	Method
Reoccurrence of atrial fibrillation as evidenced by electrocardiogram and changes in echocardiography heart rate variability during post-procedure follow-up