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Clinical Trials/NCT01133964
NCT01133964
Completed
Not Applicable

Dairy Proteins and Postprandial Appetite Regulation and Energy Expenditure

University of Copenhagen1 site in 1 country22 target enrollmentStarted: October 2008Last updated:
ConditionsObesity

Overview

Phase
Not Applicable
Status
Completed
Enrollment
22
Locations
1
Primary Endpoint
Subjective appetite sensation

Overview

Brief Summary

The aim of this study is to examine the effect of dairy proteins (whey and casein) on postprandial appetite regulation and energy expenditure.

Detailed Description

Several studies have shown that a high protein intake is associated with a increased loss of body weight and body fat as compared to a diet with a normal or low protein content. The effect seems to be due to a higher diet induced thermogenesis and increase satiety.

Milk has a high content of proteins. It contains two very different types of protein: whey and casein. Whey is a soluble protein whereas casein clots into the stomach, which delays its gastric emptying and thus probably results in a slower release of amino acids. It is therefore very likely that the two types of protein affect the thermogenesis and appetite regulation differently.

The aim of the present study is to examine the effect of dairy proteins (whey and casein) on postprandial energy expenditure, substrate oxidation and appetite regulation.

The study will have a cross-over design including four meals each including a test drink (milk, casein drink, whey drink or water).

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Prevention
Masking
Single (Investigator)

Eligibility Criteria

Ages
18 Years to 50 Years (Adult)
Sex
Male
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • healthy males
  • body mass index (BMI) 25-30 kg/m2
  • 18-50 years
  • weight stable

Exclusion Criteria

  • regular use of medicine
  • elitist athletes
  • participation in other intervention studies

Outcomes

Primary Outcomes

Subjective appetite sensation

Time Frame: 5 hours

Energy expenditure

Time Frame: 5 hours

Substrate oxidation

Time Frame: 5 hours

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other

Study Sites (1)

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