Effect of Dexamethasone on Postoperative Inflammatory Factors
- Registration Number
- NCT04981093
- Lead Sponsor
- General Hospital of Ningxia Medical University
- Brief Summary
This topic foe randomized prospective study.Detection of elderly patients with lunmbar spinal postoperative inflammatory substances in the blood and drainage of liquid level ,clear whether low-dose dexamethasone can inhibit the inflammation, the observation of elderly patients with lumbar spinal postoperative drainage star, to explor whether low-dose dexamthasone can reduce postoperative incision drainage, thus impove the postoprative drainage tube pull rate within three days, which in turn reduce because of the place a retrograde infection caused by drainage tube.
- Detailed Description
A total of 100 patients undergoing posterior lumbar disc fusion were randomly divided into control group (group C,n=50) and dexamethasone group (group D,n=50). Group D was given 0.15mg/kg dexamethasone (2ml) intravenously after anesthesia induction. Group C was also intravenously injected with 2ml normal saline after anesthesia induction.On this basis, monitor the main results and secondary results
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- Adult patients ≥65years of age
- American Society of Anesthesiologists (ASA) physical status 2-4
- Elective or expedited non-cardiac surgery of at least 2 hours dura- tion under general anaesthesia
- Requiring a hospital stay of at least one postoperative night
- A surgical skin incision >5 cm in length or multiple incisions with a total incision length of >5 cm
·
- Poorly controlled diabetes (HbA1c>9.0%)
- Endovascular procedure with a small (<5 cm length) skin incision Ophthalmic surgery
- Planned dexamethasone (or other corticosteroid) therapy (eg, history of intractable PONV, maxillofacial surgery, intracranial neurosurgery)
- Recent (<2 weeks since end of treatment) infective episode requir- ing treatment with antibiotics
- Chronic antibiotic therapy (eg, for bronchiectasis, cystic fibrosis etc)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group Dexamethasone Dexamethasone Injection Group dexamethasone patients received intravenous injection after anesthesia induction Injection 0.15mg/kg dexamethasone (2ml） Group Saline Normal saline Group Control patients were also given 2ml of normal saline intravenously after induction of anesthesia
- Primary Outcome Measures
Name Time Method the change of Inflammatory mediators in the drainage fluid 6 hours after surgery， the morning of 1, 2, and 3 days after surgery CRP(mg/ L) in postoperative drainage fluid was observed
the change of drainage fluid volume 6 hours after surgery， the morning of 1, 2, and 3 days after surgery Drainage fluid （ml）was collected and the volume of drainage fluid was recorded
Until the drainage tube was pulled out,
- Secondary Outcome Measures
Name Time Method the change of blood inflammatory mediators 6 hours after surgery， the morning of 1, 2, and 3 days after surgery Fasting blood was collected from each enrolled patient preoperatively, 6 hours after surgery and on the morning of 1, 2, and 3 days after surgery
Fasting blood, blood samples were centrifuged (1500r/min, 15min) and serum was separated and placed in -80℃ deep low temperature refrigerator for measurement. The observation technique
After the blood CRP(mg/l)the change of blood routine white blood cell count 6 hours after surgery， the morning of 1, 2, and 3 days after surgery Fasting blood was collected from each enrolled patient preoperatively, 6 hours after surgery and on the morning of 1, 2, and 3 days after surgery
Fasting blood, blood samples were centrifuged (1500r/min, 15min) and serum was separated and placed in -80℃ deep low temperature refrigerator for measurement. The observation technique
After the blood blood routine white blood cell count
Trial Locations
- Locations (1)
General Hospital of Ningxia Medical University
🇨🇳Yinchuan, Ningxia, China