NCT05734235已完成1 期
Ultraviolet B Radiation-Induced Microvesicle Particle Release in Human Skin
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 8
- 试验地点
- 2
- 主要终点
- Change in microvesicle particles (MVP) levels from baseline
研究概览
简要总结
This study is designed to assess if ultraviolet B radiation (UVB) found in sunlight causes the release of microvesicle particles in human skin, and if antioxidant vitamins can block their production.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Male subjects
- •Ages 21 to 45
- •Skin type: Fitzpatrick Type I or II
排除标准
- •Have underlying diseases that could affect wound healing
- •On medications that are known photosensitizers (e.g., doxycycline) or anti-inflammatories (e.g., NSAIDS [except for low-dose aspirin] or steroids)
- •History of abnormal scarring (e.g., keloids)
- •Should not be on Vitamin C or E supplements for past month
- •Unable to understand/complete informed consent
- •Large volar arm tattoos that would inhibit the ability to conduct/evaluate the skin testing
- •Renal compromise/kidney stones or allergy to Vitamin C/Vitamin E or lidocaine anaesthetic
- •Use of tanning bends or recent UVB exposure to the areas in the past 3 months
- •Recent (within 1 week) use to sunscreen to volar forearms
结局指标
主要结局
Change in microvesicle particles (MVP) levels from baseline
时间窗: Day 8
Levels of microvesicle particles will be determined from skin biopsies
次要结局
未报告次要终点
研究者
研究点 (2)
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