Training of Neural Responding in BPD
Not Applicable
- Conditions
- F60.31
- Registration Number
- DRKS00009363
- Lead Sponsor
- Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 25
Inclusion Criteria
Current BPD (= 4 DSM-V criteria), female, informed consent for study participation
Exclusion Criteria
Psychotropic medication with tranquilizers, lifetime diagnosis of schizophrenia or bipolar I, substance dependence in the preceding year, current substance use, pregnancy, epilepsy, antecedent cranial or brain injuries, organic brain diseases, severe medical or neurological condition, BMI<16.5, metallic non-removable items in or on the body which are not MR compatible, permanent make-up, claustrophobia, left-handedness
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Target criterion: Improvement of emotion regulation. Measures: Questionnaire: Difficulties in Emotion Regulation Scale (DERS); Peripheral physiologic measures: Fear-potentiated startle with instructed emotion regulation vs. natural responding to emotional pictures, heart rate variability (relation of high vs. low frequencies in spectrum). Central nervous system measures: amygdala BOLD response to masked affective facial expressions, amygdala BOLD response in Sternberg-Working Memory test with emotional vs. neutral distractor images. Acquisition times: T0: Treatment group: max 7 days before first training session (depends on patient's availability), T1: max 7 days after third training session, T2 (Follow up): 6 weeks after T1
- Secondary Outcome Measures
Name Time Method Target criterion: Reduction of BPD symptom severity. Measures: ZAN-BPD structured interview (acquisition in T0 and T2), BSL-23 self-report questionnaire (acquisition in T0, T1, T2; time lag matched to treatment group).