Effects of Valerian on Prevention of Cognitive Impairment
Not Applicable
- Conditions
- Cognitive Impairment.Other specified mental disorders due to brain damage and dysfunction and to physical disease
- Registration Number
- IRCT201311104190N2
- Lead Sponsor
- Vice chancellor for research, Islamic Azad University, Sari Branch
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
1.Patients aged between 30-70 years.
2.Coronary artery bypass surgery with cardiopulmonary bypass
Exclusion criteria:
1.Other simultaneous cardiac surgery (e.g., Valve replacement)
2.Symptomatic cerebrovascular disease
3.Alcoholism
4.Psychiatric illness (any clinical diagnosis requiring therapy)
5.Drug abuse
6.Hepatic insufficiency (liver function tests>1.5 times the upper limit of normal)
7.Severe pulmonary insufficiency (requiring home oxygen therapy)
8.Renal failure (serum creatinine>2mg/dl)
9.Reluctance to do a cognitive test performance
10.Previous heart surgery
11.Preoperative left ventricular ejection fraction<30%
12.Sensitivity to valerian
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive Impairment. Timepoint: Before intervention-ten days after beginning of intervention-two month after beginning of the intervention. Method of measurement: Mini Mental State Examination.
- Secondary Outcome Measures
Name Time Method Any reaction to valerian. Timepoint: Ten days after beginning of intervention-two month after beginning of the intervention. Method of measurement: Observation.