Effects of Smoking Environment on Craving and Smoking

Not Applicable

Completed

• Conditions: Smoking

• Registration Number: NCT02416986
• Lead Sponsor: Duke University

Brief Summary

The goal of this study is to evaluate the effects of exposure to standard smoking environments on ability to resist smoking as measured with a Delay to Smoking Task. The results of this study will inform whether the Delay to Smoking Task is a sensitive measure for evaluating environment-provoked craving and smoking behavior.

Detailed Description

Adult smokers (n=25) will complete 4 visits and a 6 month follow-up phone call. Participants will complete a Delay to Smoking Task following 6 hours smoking abstinence. The task involves viewing pictures of smoking and non-smoking locations and participants will have the choice to smoke a cigarette at any time during the session. A monetary reinforcer will be provided for each 6-minute period that a participant resists smoking. Once participants stop the task they can choose to smoke as much or a little as they want for the next 30 minutes. Participants will be provided with a smoking tab. Each cigarette they light will cost them from their tab. Measurements of tobacco craving, emotion ratings, and nicotine withdrawal will be assessed.

Study Timeline

• Study Start: 2014-10
• Study First Submitted: 2015-04-08
• Study First Submitted QC: 2015-04-14
• Study First Posted: 2015-04-15
• Primary Completion: 2015-07
• Study Completion: 2015-12
• Status Verified: 2016-08
• Last Update Submitted: 2017-01-30
• Last Update Posted: 2017-01-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• generally healthy
• between the ages of 18 and 55
• smoking an average of 5 cigarettes per day for at least one year
• breath CO level > 8 ppm (if ≤ 8 ppm, then NicAlert Strip = 6)
• no interest in quitting smoking for the duration of time required for the experiment

Exclusion Criteria

• inability to attend all required experimental sessions
• use of psychoactive medications
• use of smokeless tobacco
• current alcohol or drug abuse
• use of illegal drugs as measured by urine drug screen (excluding marijuana)
• current use of nicotine replacement therapy or other smoking cessation treatment
• Blood Alcohol Level (BAL) > 0.00
• use of other tobacco products or e-cigarettes more than 9 days in the past 30 days

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in self-report craving measured by the cue-exposure rating scale	at 0 minutes, +30 minutes, +60 minutes and following first cigarette
Difference in number of subjects who initiate smoking during the smoking cue Delay to Smoking Task compared to the nonsmoking cue Delay to Smoking Task	following start of Delay to Smoking Task, up to 60 minutes	If participant initiates smoking a cigarette during the Delay to Smoking Task
Number of minutes to first puff	following start of Delay to Smoking Task, up to +60 minutes	Number of minutes to first puff of cigarette will be recorded for participants that initiate smoking

Trial Locations

Locations (1)

Duke University Medical Center; 🇺🇸 Durham, North Carolina, United States