The Effect of Dietary Nitrates on Physical Performance and Vascular Function in Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- Microvascular Function, assessed by laser Doppler flowmetry coupled with intradermal microdialysis
研究概览
简要总结
The purpose of this study is to examine the effect of acute ingestion of a concentrated beetroot juice supplement on vascular function and exercise capacity in patients with moderate to severe chronic kidney disease
详细描述
People with Chronic Kidney Disease (CKD) are at an increased risk of cardiovascular disease. Blood vessel dysfunction and exercise intolerance are common in CKD. Blood vessel dysfunction has been shown to predict future cardiovascular events and decreased physical activity can contribute to an increased risk of cardiovascular disease. Therefore, this study investigates if dietary nitrate from beetroot juice, which has been shown to improve blood vessel function and exercise capacity in other cardiovascular disease pathologies, could be effective at improving these measures in patients with CKD. In a controlled, double blinded trial, stage 3-5 CKD patients will be randomly assigned to receive either beetroot beverage or a placebo and then complete measures of blood vessel function and an exercise test.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Stage 3-5 Chronic Kidney Disease
排除标准
- •History of cardiovascular disease
- •Current pregnancy
- •Uncontrolled hypertension
- •Uncontrolled hyperlipidemia
- •Current hormone replacement therapy
- •Current use of tobacco products
- •Current autoimmune disease
- •Current hyperkalemia
- •Diagnosis of a deep vein thrombosis (DVT) within the last 6 months
研究组 & 干预措施
Beet Juice Supplement
A single, acute dose of Beet It Sport Shot containing ~12.6mmol naturally occurring dietary nitrates.
干预措施: Beet It Sport Shot (Dietary Supplement)
Placebo juice
A single, acute dose of nitrate-depleted Beet It Sport Shot
干预措施: Nitrate-depleted placebo (Dietary Supplement)
结局指标
主要结局
Microvascular Function, assessed by laser Doppler flowmetry coupled with intradermal microdialysis
时间窗: 2.5 hours post ingestion of juice
Nitric oxide mediated cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with microdialysis
次要结局
- Pulse wave analysis(2.5 hours post ingestion of juice)
- Arterial stiffness(2.5 hours post ingestion of juice)
- Blood pressure(Change from pre-ingestion baseline to 2.5 hours post ingestion of juice)
- Peak aerobic capacity(2.5 hours post ingestion of juice)
- Endothelial function(2.5 hours post ingestion of juice)