Effects of light on emotional processing

Completed

Conditions: Parkinsons's disease
symptoms of depression
10028037
10027946

Registration Number: NL-OMON47762

Lead Sponsor: VU Medisch Centrum, Amsterdam UMC

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Depression:
- Age > 40 years
- Significant symptoms of depression (score > 13 on the Inventory of Depressive Symptomatology (IDS-SR))40
- Symptomatic on the depression part of the Composite International Diagnostic Interview * Short Form (CIDI-SF)41
- Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements.;PD:
- Age > 40 years
- Idiopathic PD, as diagnosed by the UK Brain Bank Criteria
- Mild PD stage 1-3, based on Hoehn & Yahr scale
- Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements
- MMSE 24;Control:
- Age > 40 years
- Willingness and ability to give written informed consent and willingness and ability to understand, to participate and to comply with the study requirements.

Exclusion Criteria

PD
- Early onset PD (< 40 years)
- Treatment with continuous apomorphine infusion, intestinal duodopa therapy or deep brain stimulation (DBS);- PD patients with excessive tremor.;Control:
- Current or past psychiatric diagnosis
- Significant symptoms of depression (score > 13 on the IDS-SR)
- Symptomatic on the CIDI-SF.;All groups
- Current diagnosis of bipolar disorder, psychotic disorder, alcohol or substance dependence, or any cognitive disorder
- Neurological disease (other than PD for the PD group) stroke or major head trauma, current or in history
- MRI contraindications such as metal implants, claustrophobia, left-handedness, pregnancy
- Self-reported inability or unease to cease smoking for 24 hours prior to testing
- Current treatment with tricyclic antidepressant or antipsychotic medication
- Ophthalmic disorder, color blindness, severe visual impairment or auditory impairment
- Travel to a different time zone within the last month
- Night work or rotating shift work.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Our main study endpoints include 1) Blood Oxygenation Level Dependent Signal<br /><br>(BOLD) in people with PD and persons with symptoms of depression compared with<br /><br>controls</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>2) PD and depressive symptoms and their correlation to brain sensitivity to<br /><br>light; 3) Anatomical connectivity as measured with diffusion tensor imaging<br /><br>(DTI); 4) Daily subjective mood and its correlation to 24-hour ambient light<br /><br>exposure patterns and body temperature rhythm, the sleep wake cycle and brain<br /><br>sensitivity to light.</p><br>