Sleep Characteristics in Post-Corona Virus Disease 2019 Patients Compared to Healthy Controls - An Observational Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Post-COVID-19
- Sponsor
- Schön Klinik Berchtesgadener Land
- Enrollment
- 31
- Locations
- 1
- Primary Endpoint
- Apnea-Hypopnea-Index (AHI)
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
After acute infection, patients with coronavirus disease 2019 (COVID-19) often suffer from persisting symptoms for more than 3 months (post COVID-19). Sleep disorders (31%) have already been assessed by questionnaires and interviews in post-COVID-19, but have not yet been proven by polysomnography (PSG), the gold standard for sleep testing. This study aimed to measure sleep characteristics in post-COVID-19 patients.
Detailed Description
Hypothesis: We hypothesize that post-COVID-19 patients have a significantly higher apnea-hypopnea index (AHI) during sleep compared to healthy controls. 15 post-COVID-19 patients and 15 healthy controls will perform a baseline assessment on day 1 including a 1-minute sit-to-stand test (STST), post-COVID functional scale (PCFS), Ordinal Scale for Clinical Improvement (OSCI), history of COVID-19, social anamnesis, Pittsburgh Sleep Questionnaire and subjective limitations of sleep. On day 4, after an initialization phase for WHOOP strap (a digital fitness and health coach), all patients performed a single night sleep assessment in a sleep lab via Polysomnography and WHOOP.
Investigators
Prof. Dr. Andreas Rembert Koczulla
Principal investigator
Schön Klinik Berchtesgadener Land
Eligibility Criteria
Inclusion Criteria
- •Post-COVID-19 Group:
- •Patients after SARS-CoV-2 infection with signs of Post-COVID-19
- •≥18 years
- •written informed consent
- •Healthy controls:
- •No history of SARS-CoV-2 infection
- •≥18 years
- •written informed consent
Exclusion Criteria
- •Post-COVID-19 Group:
- •Diagnosis of a breathing-related sleep disorder before SARS-CoV-2 infection
- •BMI \>25kg/m2
- •Healthy controls:
- •Diagnosis of a breathing-related sleep disorder
- •BMI \>25kg/m2
Outcomes
Primary Outcomes
Apnea-Hypopnea-Index (AHI)
Time Frame: One single night on study day 4
Number of apnea or hypopnea Events per hour of sleep
Secondary Outcomes
- Mixed apnea(One single night on study day 4)
- Light sleep phase(One single night on study day 4)
- Periodic leg movement Index(One single night on study day 4)
- Obstructive apnea(One single night on study day 4)
- Central apnea(One single night on study day 4)
- Rapid Eye Movement (REM) sleep phase(One single night on study day 4)
- Deep sleep phase(One single night on study day 4)