The effect of LSD on neural synchrony, prosocial behavior, and relationship quality

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 60

Inclusion Criteria

Written Informed Consent

Understanding the procedures and the risks associated with the study.

Age between 18 and 40 years old.

Being in a steady relationship for at least 6 months.

Proficient knowledge of the English language

Previous experience with at least one psychedelic drug (psilocybin, LSD,
mescaline, Ayahuasca, DMT, 5-MeO-DMT), but not within the past 3 months

Absence of any major medical condition as determined by medical examination and
laboratory analysis

Absence of any major psychological condition as determined by medical
examination

Free from psychotropic medication

Participants must be willing to refrain from taking illicit psychoactive
substances during the study.

Participants must be willing to drink only alcohol-free liquids and no coffee,
black or green tea, or energy drink after midnight of the evening before the
study session, as well as during the study day.

Participants must be willing not to drive a traffic vehicle or to operate
machines within 24 h after substance administration.

Normal weight, body mass index (weight/height2) between 18 and 28 kg/m2

Exclusion Criteria

History of drug addiction (determined by the medical questionnaire, drug
questionnaire and medical examination)

Previous experience of serious side effects to psychedelic drugs (anxiety or
panic attacks)

Pregnancy or lactation

Hypertension (diastolic > 90 mmHg; systolic > 140 mmHg)

Current or history of psychiatric disorder (determined by the medical
questionnaire and medical examination)

Psychotic disorder in first-degree relatives

Any chronic or acute medical condition

History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)

For women: no use of a reliable contraceptive

Tobacco smoking (>20 per day)

Excessive drinking (>20 alcoholic consumptions per week)

Experience with a full dose of a psychedelic within the last three months

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quantification of neural synchrony (defined as EEG phase locked values) between<br /><br>couples utilizing previously validated naturalistic interaction paradigms.<br /><br>Specifically during the motor cooperation task, empathy giving task, and<br /><br>affective touch and eye contact paradigm.</p><br>

Secondary Outcome Measures

Name	Time	Method

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