Improved Orthostatic Tolerance = Better Cognitive Function in Parkinson's Disease: Does a Successful Treatment of Orthostatic Hypotension Measurably Enhance Attention and Memory Functions in Parkinson's Disease
Overview
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- RWTH Aachen University
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Blood Pressure in mmHg
Overview
Brief Summary
Study on orthostatic Hypotension in Parkinson's disease
Detailed Description
Orthostatic hypotension (OH) in Parkinson's disease (PD) may not only be related to dizziness or light headedness but to deficits in attention, visual, and verbal memory. Would a successful treatment of OH which includes physiotherapy significantly improve OH and these cognitive deficits? By means of a randomized cross-over trial, we want to measure and compare the effects of OH therapy on orthostatic tolerance, as well as on attention, visuo-spatial working memory, and verbal memory in patients with PD. If confirmed, therapy of orthostatic hypotension would provide a sound and simple approach to improve those cognitive deficits originating from orthostatic hypotension.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Supportive Care
- Masking
- Single (Investigator)
Eligibility Criteria
- Ages
- 40 Years to 95 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Parkinson's patients
- •Diagnostis of OH
- •able to perform an ambulatory physiotherapy at Aachen University Hospital.
Exclusion Criteria
- •deep brain stimulation or Pacemaker
- •severe psychiatric disease
- •severe heart disease
- •severe vascular encephalopathy
- •pregnant or lactating women
- •extreme pain or immobility
Outcomes
Primary Outcomes
Blood Pressure in mmHg
Time Frame: 10months
Systolic postural blood pressure drop in the interventional Group (Long_Physiotherapy) less than 10mmHg (5-15mmHg) compared to Short_Physiotherapy
Secondary Outcomes
- Orthostatic symptoms (Winkler Scale)(10months)
- daytime sleepiness(10months)
- Attention in TAP(10months)
Investigators
Andrea Maier
attending physician and investigator
RWTH Aachen University