Effects of Intranasal Oxytocin on Striatal Functional Connectivity

Not Applicable

Completed

• Conditions: Healthy
• Interventions: Drug: Oxytocin; Drug: Placebos

• Registration Number: NCT03128203
• Lead Sponsor: University of Electronic Science and Technology of China

Brief Summary

To investigate whether 40 IU of intranasal oxytocin treatment can influence the resting-state functional connectivity in healthy males.

Detailed Description

In a double-blind, between-subject, placebo controlled design, investigators plan to investigate the effects of oxytocin treatment on resting-state functional connectivity.

Subject will receive either intranasal oxytocin or placebo administration and go through a seven-minute resting-state scan in MRI scanner to test whether oxytocin changes functional connectivity in the brain. Trait anxiety and mood questionnaires will be administered as control variables.

Study Timeline

• Study Start: 2016-09
• Primary Completion: 2017-02
• Status Verified: 2017-04
• Study Completion: 2017-04
• Study First Submitted: 2017-04-20
• Study First Submitted QC: 2017-04-20
• Last Update Submitted: 2017-04-20
• Study First Posted: 2017-04-25
• Last Update Posted: 2017-04-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 135

Inclusion Criteria

• healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

• with MRI Contraindications

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Oxytocin	Oxytocin	-
Placebo	Placebos	-

Primary Outcome Measures

Name	Time	Method
Striatal functional connectivity alterations after drug administration	45 minutes after drug administration	fMRI-based resting state connectivity of the striatum will be compared between the oxytocin and the placebo group

Trial Locations

Locations (1)

School of Life Science and Technology, University of Electronic Science and Technology of China; 🇨🇳 Chengdu, Sichuan, China