Customised topographic photorefractive keratectomy (PRK) followed by corneal cross-linking in a single procedure for progressive keratoconus

Completed

• Conditions: Keratoconus; Eye Diseases; Other disorders of cornea

• Registration Number: ISRCTN57262986
• Lead Sponsor: Azienda Ospedaliera Policlinico di Bari (Italy)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-02-18
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Documented progressive keratoconus
2. Corneal thinnest point: 450 micra
3. Hard contact lens and full spectacle correction intolerance
4. Aged over 18 years, either sex

Exclusion Criteria

1. Corneal thinnest point less than 450 micra
2. History of ocular morbidity
3. Previous ocular surgery

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Measured at 1, 3, 6, 12, and 18 months:<br>1. Visual acuity<br>2. Refraction<br>3. Corneal aberrations<br>4. Corneal topography

Secondary Outcome Measures

Name	Time	Method
Measured at 1, 3, 6, 12, and 18 months:<br>1. Confocal microscopy<br>2. Anterior segment optical coherence tomography