Importance of white cell, platelet cell ratio in long standing obstructive lung disease

Completed

Conditions: Chronic obstructive pulmonary disease, unspecified,

Registration Number: CTRI/2024/03/063588

Lead Sponsor: Dr Satya Roy

Brief Summary: At present, there have been few articles with varying results on the association of neutrophil to lymphocyte (NLR) ratio and platelet to lymphocyte (PLR) ratio in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) compared to stable COPD patients. NLR and PLR are easily accessible and inexpensive markers that have the potential to assist in the risk stratification of hospitalized AECOPD patients, particularly in resource-limited settings, and improve patient outcomes with timely intervention.

Several studies have shown that NLR levels were higher in patients with AECOPD than in stable-state COPD patients, implying that NLR levels can be used as a marker of acute exacerbation. Levels of PLR were also found to be significantly higher in patients who required mechanical ventilation. It was also seen that mean levels of NLR and PLR among patients admitted to ICU were significantly higher among non-survivors compared to survivors of AECOPD.

The combination of NLR, PLR, and CRP have been shown to increase the prognostic sensitivity. It has been concluded that NLR may be an easily available and inexpensive marker for mortality in patients with AECOPD.

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 242

Inclusion Criteria

CASES- 1) Patients with diagnosis of acute exacerbation of COPD defined as acute worsening of respiratory symptoms such as breathlessness, cough with sputum severe enough requiring hospital admission CONTROLS- 1) Clinically stable COPD patients diagnosed on the basis of GOLD guidelines admitted for other reasons in the medical ward or from the medicine and pulmonary medicine outpatient clinic will be taken as controls.

Exclusion Criteria

1)Patients with bronchial asthma 2)Patients with bronchiectasis 3)Pulmonary tuberculosis patients 4)Patients on oral steroid treatment 5) Patients with other infective conditions- UTI, sepsis due to other causes etc 6)Patients with other inflammatory conditions-inflammatory arthritis, inflammatory bowel disease 7)Patients with autoimmune conditions- SLE etc 8)Patients with hematological disorders 9)Patients with malignancies 10)Patients with a recent MI/stroke.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To correlate NLR PLR, Procalcitonin, CRP, clinical outcome	at the time of recruitment

Secondary Outcome Measures

Name	Time	Method

Trial Locations

Locations (1): Kasturba hospital manipal
🇮🇳
Udupi, KARNATAKA, India
Kasturba hospital manipal
🇮🇳Udupi, KARNATAKA, India
Dr Satya Roy
Principal investigator
9006805672
medicosatyaroy@gmail.com