Association Study of Gene Polymorphisms With Cardiac Performance

• Conditions: Coronary Artery Disease; Genetic Polymorphism; Hemodynamics

• Registration Number: NCT00730899
• Lead Sponsor: University Hospital, Essen

Brief Summary

The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Detailed Description

G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Study Timeline

• Study Start: 2008-05
• Status Verified: 2008-08
• Study First Submitted: 2008-08-04
• Study First Submitted QC: 2008-08-04
• Last Update Submitted: 2008-08-04
• Study First Posted: 2008-08-08
• Last Update Posted: 2008-08-08
• Primary Completion: 2011-01
• Study Completion: 2011-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• clinical diagnosis of coronary artery disease
• patients scheduled for coronary artery bypass grafting

Exclusion Criteria

• emergency operation
• combined vitium

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
genotype dependent change of hemodynamic variables	one day

Secondary Outcome Measures

Name	Time	Method
all cause mortality	60 days

Trial Locations

Locations (1)

University Hospital; 🇩🇪 Essen, Nordrhein-Westfalen, Germany