Repeated Injection of I PRF and Autogenous Bone Graft for Alveolar Ridge Augmentation

Not Applicable

Completed

• Conditions: Alveolar Bone Loss; Alveolar Ridge Abnormality

• Registration Number: NCT06711250
• Lead Sponsor: Ain Shams University

Brief Summary

The current st udy's objective was to validate the repeated effect of i PRF with autogenous bone on the of gingival thickness , width a n d volumetric bone changes durig maxillary alveolar augmentation using cone beam computer tomography (CBCT). Patients and methods:

Detailed Description

The study was a randomized clinical study in which participants needed to augment defective ridge were selected from the Outpatient Clinic, Department of Oral Medicine, Periodontology and Diagnosis , Faculty of Dental Medicine for Girls, Al Azhar University. The Research Ethics Committee, Faculty of Dental Medicine for Girls, Al Azhar University (REC code (P. PD 24 19 ) certified this study and a signed informed consent form with approval was obtained from each. Each patient who was enrolled in the study had a complete medical record and a proper clinical examination. These patients had to have a horizontal or vertical alveolar ridge deficiency and have enough bone in the mandibular donor site (external oblique ridge).

However, patients showing any signs of active periodontal disease, on long term corticosteroid therapy, persons taking bone metabolism drugs as well as individuals suffering from any systemic illness that may impact bone repair were excluded from the study.

Patients were assigned to one of two 2 groups, group I or group II. Group I, consisted of patients grafted with autogenous bone graft alone. I n Group II, patients were grafted using autogenous bone combined with repeated injection of i PRF Assessment of the alveolar ridge dimension and the bone block to be harvested preoperatively using CBCT. T he measurements of the alveolar ridge mesio distaly and bucco lingually in mm were determined at the recipient site . It was crucial to visualize the anatomic structures at the osteotomy site, including the alveolar canal, the mental foramina, and the teeth roots present to create ideal bone cutting planes according to the depth and extension of the graft without any injuries to the aforementioned structures.

Study Timeline

• Study Start: 2024-04-01
• Primary Completion: 2024-09-01
• Status Verified: 2024-11
• Study Completion: 2024-11-01
• Study First Submitted: 2024-11-22
• Study First Submitted QC: 2024-11-28
• Last Update Submitted: 2024-11-28
• Study First Posted: 2024-12-02
• Last Update Posted: 2024-12-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 28

Inclusion Criteria

• patients who have a horizontal or vertical alveolar ridge deficiency

Exclusion Criteria

• patients showing any signs of active periodontal disease
• patients on long term corticosteroid therapy,
• patients taking bone metabolism drugs
• patients suffering from any systemic illness that may impact bone repair

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
width of the alveolar ridge	baseline, 6 months & 9 months	CBCT will be used to assess the width of the alveolar ridge

Secondary Outcome Measures

Name	Time	Method
volumetric analysis of bone	at baseline, 6 and 9 months	volumetric analysis ob bone using CBCT to assess the bone volume

Trial Locations

Locations (1)

Faculty of Dentistry , Al Azhar Univeristy For Girls; 🇪🇬 Cairo, Heliopolis - Cairo, Egypt